Acs Dobfar S.p.a.

Leonardo Marsili

Maurizio Zenoni

Antonio Manca

Riccardo Monguzzi

Angelo Giovanni Cattaneo

Mario Leone

A sterile pharmaceutical composition having as its active principles piperacillin sodium and tazobactam sodium of substantially the same density, mixed with sodium bicarbonate. The mixture is soluble in water to give injectable reconstituted solutions having high stability with time.

Injectable sterile pharmaceutical composition with piperacillin sodium and tazobactam sodium as active principles

Mixtures of at least two active principles, of which at least one is the sodium salt, are precipitated from an organic solution containing the same active principles in salified or non-salified acid form.

Injectable sterile pharmaceutical formulation containing at least two active principles

Cefalotin is methoxylated in position 7&#x3b1;, desacetylated and then carbamoylated in position 3, to provide acid cefoxitin without any isolation of intermediate products. The acid cefoxitin is then transformed into the sodium salt by means of ion exchange resin.

Process for preparing sodium cefoxitin

Process for producing Cefepime, Cefpirome and Cefquinome, whereby a cephalosporin containing a quaternary ammonium group is reacted with thiourea to provide the aforesaid cephalosporins.

Process for producing Cefepime and cephalosporin analogues

Cephalosporins may be conveniently prepared by a process in which a benzathinium salt of formula (V) wherein:

Process for preparing cephalosporins with salified intermediate

A bioavailable crystalline form of cefuroxime axetil, obtained by treating known crystalline or amorphous cefuroxime axetil with water or with a water-miscible organic solvent or with a mixture thereof at a temperature of between +20.degree. C. and +100.degree. C., followed by cooling and separating the crystalline product by known methods.

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Brescia, Italy

Leonardo Marsili