The United States of America, As Represented by the Secretary, Department of Health and Human Services

University of Cincinnati

Leonard W Mayer

Xin Wei Wang

Jennifer Thomas

Raydel Anderson

Mary Jordan Theodore

Cynthia Hatcher

Xin Wang

Errol Reiss

Timothy J Lott

Rosely M Zancope-Oliveira

George S Deepe

Jennifer Dolan Thomas

A process for detectingnucleic acid in a sample includes producing an amplification product by amplifying anucleotide sequence and measuring the amplification product to detectin the sample. Some embodiments allow direct serotype determination in a single step assay. Also provided are reagents and methods for detecting and distinguishingfrom other infectious agents. A kit is provided for detecting and quantifyingin a sample.

Selective detection of

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The present invention provides the nucleotide sequence of the M antigen gene of, which is set forth in the Sequence Listing as SEQ ID NO:1, a nucleic acid having the nucleotide sequence complementary thereto, and nucleic acids having a nucleotide sequence which is substantially the same as the foregoing nucleotide sequences. The present invention also provides vectors and host expressions systems containing the foregoing nucleic acids, and isolated or recombinantly-produced antigens encoded by the foregoing nucleic acids. The present invention further provides antibodies generated against the foregoing antigens, and methods and kits for detecting a previous or currentinfection in a subject, and for diagnosing histoplasmosis.

Growing community of inventors

Decatur, GA, United States of America

Leonard W Mayer