Corvita Corporation

Cordis Corporation

Infocus Corporation

Mayser, LLC

Surefire Medical, Inc.

Other

Boston Scientific Scimed, Inc.

Innovia LLC

Scimed Life Systems, Inc.

Schneider (usa) Inc.

Medical Engineering Corporation

Trisalus Life Sciences, Inc.

University of Miami

Ripple Therapeutics Corporation

Boston Scientific Corporation

Leonard Pinchuk

John B Martin

Gary A Kalser

Gregory L Mayback

James E Chomas

Thomas N Trotta

Robert S Shonk

Bryan Pinchuk

Aravind Arepally

James Ernest Leone

Brett E Naglreiter

David C MacGregor

Norman R Weldon

Stefan A Jackowski

Jean-Pierre Georges Dereume

Marlene C Schwarz

Kalpana Kamath

Yonghua Zhou

Jean-Marie Arthur Parel

George Bourne

Saul Gottlieb

Yongmoon Kwon

Francisco Fantes

Yasushi Pedro Kato

Anh Le

James Leone

Charles R Slater

Ni Ding

Charles E Larsen

Banning Gray Lary

Suranjan Roychowdhury

Thomas D Weldon

Sepideh H Nott

Eugen Hofmann

Jennifer E Raeder-Devens

Susanne Hankh

Michael G O'Connor

Jeannine B Baden

Daniel J Klima

John A Shimkus

Bruce A Weber

Sepideh Hashemi

Matthew A Palmer

Claude O Clerc

Paul J Thompson

Matthew P Palmer

Paul F Chouinard

John Hillerich Martin

Noureddine Frid

Arthur L Rosenthal

Norman L Block

Ian Charles Parrag

Matthew Alexander John Statham

Hans Christian Fischer

Kyle Giovanni Battiston

Wendy Alison Naimark

Dimitra Louka

Sandra L Miller

James A Kane

David Pinchuk

Ashraf A Ismail

Terri L Tessmann

Eugene C Eckstein

Jean-Pierre Georges Emile Dereume

Gary M Kalser

Terri L Tessman

Anne A Maurin

Kevin J Clair

Yasushi Kato

David S Edelman

Rysler Alcime

Yasushi P Kato

I John Khan

Jacob Kline

Orley R Pinchuk

G Banning Lary

Louis J Tullo

Bryan M Pinchuk

John Martin

David Macgregor

An endovascular system includes inner and outer catheters, a handle system operably coupled one end of the catheters, and a microvalve coupled to the other end of the catheters. The microvalve is constrained in a radially-collapsed closed configuration for advancement within a vessel to a treatment site. The handle system is operable to displace the inner and outer catheters portions relative to each other to move the microvalve between closed and open configurations. An indicator is provided to visually indicate the extent by which the microvalve is opened within the vessel.

Dynamic microvalve protection device

An inserter device is provided for use with a glaucoma drainage device including a tube having a proximal end and a distal end with a lumen extending from the proximal end to the distal end. The inserter device includes an elongate member having a distal end defining a stop surface, and a stylus extending beyond the distal end of the elongate member. The stylus is sized and configured to be received within the lumen of the glaucoma drainage device with the stop surface interfacing to and limiting proximal movement of the glaucoma drainage device. The stylus has a first length that extends beyond the stop surface that is less than a second length of a portion of the lumen of the tube of the glaucoma drainage device that extends beyond the stop surface. Systems and methods are also described and claimed.

Glaucoma device inserter

A method of manufacturing a safety catheter includes providing a catheter having a catheter body comprising an exterior surface, a drainage lumen, and an inflation lumen, forming a balloon inflation port between the exterior surface and the inflation lumen, forming a deflation port between the exterior surface and one of the inflation and drainage lumens, fixing a balloon sleeve to the exterior surface over at least the balloon inflation port to define a fluid-tight balloon interior between an interior surface of the balloon sleeve and at least a portion of the exterior surface, removably inserting a deflation plug in the deflation port to water-tightly seal the deflation port until the deflation plug is removed, connecting a proximal portion of a deflation connector to an inside surface of one of the lumens, and connecting a distal portion of the deflation connector to the deflation plug.

Stretch valve balloon catheter and methods for producing and using same

A device implantable into the eye that includes an elongate duct portion defining two lumens that extend parallel to one another from a distal end to a neck spaced longitudinally from the distal end, a second portion including two tubular segments that extend or flare outwardly from the neck opposite one another with at least one additional tubular segment that extends between the two tubular segments such that the tubular segments of the second portion form a tubular loop that surrounds an interior area. The tubular segments of the second portion that form the tubular loop define a common lumen with a plurality of outlets that are in fluid communication with the two lumens of the duct portion to permit fluid to flow through the device.

Ocular implant

A balloon retention urinary catheter includes a porous and spongy distal tip. In one method, a polymer is mixed with sacrificial particles and the mixture is molded in the form of the tip, and then cured. The cured tip is then placed in a solvent in which the sacrificial particles elute from the tip but in which the polymer is insoluble. Once the particles elute out of the polymer in the tip, a softer porous polymeric structure results. The tip may be structured to be softer prior to use or for transformation to a softer state once in the bladder.

Soft tip drug-eluting urinary drainage catheter

A safety balloon catheter includes a catheter having a stretch valve, a connector, a balloon inflated with an inflation fluid, a hollow inflation lumen extending through the catheter to the balloon and conveying inflation fluid thereto and therefrom, a hollow second lumen, and a balloon drainage port fluidically connecting the balloon to the second lumen. The stretch valve has a hollow base fixed in the second lumen at a proximal catheter end and shaped to permit a fluid therethrough and a hollow plug slidably positioned in the second lumen at a given distance from the base to, in a steady state, prevent inflation fluid from passing through the drainage port and, when actuated, slide within the second lumen to permit inflation fluid to pass through the drainage port and into the second lumen. The connector connects the base and the plug and has a length greater than the given distance.

An implantable device for treatment of glaucoma of the eye. In one aspect, the device includes an elongate duct for diverting aqueous humor from the anterior chamber of the eye, the elongate duct having a central axis with a proximal end and distal end opposite one another. A least one element is spaced apart from the proximal end and the distal end of said elongate duct and extends radially outward beyond an outer surface of said elongate duct in at least two directions transverse to the central axis of said elongate duct, wherein the at least one element has a distal portion with a tapered profile facing the distal end of said elongate duct. The at least one element is configured to deform in a tissue passage leading into the anterior chamber of the eye as it is inserted into the tissue passage in response to forces applied by surrounding ocular tissue of the tissue passage. Other aspects are also described and claimed.

Device for treating glaucoma

A glaucoma treatment system includes a glaucoma drainage device having a flexible tube with distal and proximal ends, and an inserter with a filament that extends beyond the distal end of a rigid elongate member (e.g., rod or inserter tube). The filament is configured to detachably couple a distal portion of the drainage device tube to the elongate member of the inserter. The filament may extend through a wall of the distal portion of the drainage device tube. The filament and elongate member of the inserter can be configured for relative movement to detach the drainage device tube from the inserter. The elongate member can define an internal channel, and the filament can be configured for axial movement in this channel so that the filament may move toward the proximal end of the elongate member to detach the drainage device tube from the inserter. Other tools are described and claimed.

Tool(s) for inserting a glaucoma shunt

The disclosure relates to compounds and compositions for sustained release of ocular therapeutics.

Ocular inserts comprising a covalently linked steroid dimer

A glaucoma drainage device includes an elongated body extending axially from a distal end to a proximal end. The distal end forms a wedge with a leading distal edge. During implantation of the device into the suprachoroidal space of the eye, the wedge can facilitate penetration into and spreading open the tissue of the suprachoroidal space. The elongate body has one or more outer surfaces that define at least one open groove extending from at or near the proximal end towards the distal end of the body. With the distal end of the elongate body located in the suprachoroidal space of the eye and the distal end of the elongate body extending into the anterior chamber of the eye, the at least one open groove is configured such that aqueous humor flows along the open groove from the anterior chamber of the eye to the suprachoroidal space of the eye.

Systems, methods, and apparatus for treatment of glaucoma

A method for treating glaucoma with an implantable glaucoma device includes inserting a hollow elongated needle into the eye between the cornea and iris and into the anterior chamber of the eye to form a needle tract in the eye, introducing a distal end of a guidewire through the needle and into the anterior chamber, introducing a snare through a corneal incision into the anterior chamber. The snare has a sheath and a hook or loop inside the sheath and extendible therefrom. The method includes capturing a segment of the guidewire proximate the distal end of the guidewire with the snare within the anterior chamber, removing the needle from over the guidewire outside of the eye, coupling a glaucoma drainage device to a proximal end of the guidewire that extends outside of the eye, and pulling on the captured guidewire segment with the snare to pull the glaucoma drainage device into the needle tract and into the anterior chamber of the eye until the glaucoma device is located in an implanted position in the eye. The method can also possibly involve removing the snare from the eye, cutting a distal end of the glaucoma device (possibly within the anterior chamber), and removing the cut distal end of the glaucoma drainage device from the eye. An improved glaucoma drainage device and other deployment systems and methods are also described and claimed.

Glaucoma device delivery system and trans-conjunctival method of delivery

An apparatus includes a delivery catheter having a deployable dynamic valve that dynamically opens and closes in response to relative fluid pressure thereabout, particularly while in an anatomical lumen. The valve is maintained in a collapsed configuration during introduction to a treatment site. The valve is adapted to automatically move from the collapsed configuration to a deployed configuration at the treatment site.

An aqueous humor drainage device for implantation into a tissue passage leading into the anterior chamber of the eye. In one aspect, the device includes a flexible tube and a tissue sealing structure extending radially outward from the tube in at least two different directions. The tissue sealing structure is spaced apart from and intermediate cylindrical outer surfaces of proximal and distal portions of the tube. The tissue sealing structure extends radially outward beyond the cylindrical outer surfaces of the proximal and distal portions of the tube. The tissue sealing structure has a second maximal cross-sectional dimension that is greater than a first maximal cross-sectional dimension of the tube and is configured to interface to the tissue passage and form a seal between the tissue passage and the tissue sealing structure. Other aspects are also described and claimed.

Growing community of inventors

Miami, FL, United States of America

Leonard Pinchuk