Other

Gensia Pharmaceuticals, Inc.

Gensia, Inc.

Leonard P Miller

Harry E Gruber

Mark D Erion

Bheemarao G Ugarkar

Clinton E Browne

Angelo J Castellino

Gary S Firestein

David A Bullough

A fish processing machine that uses a large pair of refrigerated wheels to hold a fish for processing. The wheels rotate in a clockwise direction. A fish is introduced at the top of the wheels, where it is pressed against the refrigerated wheels. By the phenomenon of frost adhesion, the fish adheres to the wheels. The wheels are angled so that they are spaced closer at the top and farther apart at the bottom. As the wheels rotate, a pair of filleting knives cut the fillets from the carcass. As the wheels continue to rotate, the fillets are automatically separated by adhering to the refrigerated wheels. The remainder of the fish falls down between the wheels to a conveyer for disposal or further processing. As the wheels continue to turn, the fillets can be further processed before the fillets are removed from the skin and the skin is cleaned from the wheels.

Fish processing machine having refrigerated wheels

Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various inflammatory conditions, including arthritis and SIRS, which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.

Methods for treating adenosine kinase related conditions

The invention provides methods for preventing neural tissue damage caused by injury to the central nervous system (CNS) by the administration of a therapeutically effective amount of an adenosinergic agent. One aspect of the invention is directed toward continuous administration of a therapeutically effective amount of an adenosinergic agent for a period of time sufficient to prevent neural tissue damage. In another aspect of the present invention, the adenosinergic agents may be administered on several occasions during the prolonged period of treatment, so long as the doses of adenosinergic agents are spaced in time so that a therapeutically effective concentration of adenosinergic agent is maintained for a period of time sufficient to prevent neural tissue damage.

Methods of treating injury to the central nervous system

Growing community of inventors

Carlsbad, CA, United States of America

Leonard P Miller