University of California

The United States Government As Represented by the Department of Veterans Affairs

The Scripps Research Institute

Vault Pharma Inc.

Leonard H Rome

Valerie A Kickhoefer

Cheryl I Champion

Kathleen A Kelly

Steven M Dubinett

Sherven Sharma

Upendra K Kar

Glen R Nemerow

Cheng-Yu Lai

Mu Han

Phoebe L Stewart

Shaily Mahendra

Meng Wang

Christopher Wiethoff

Sujna Raval-Fernandes

Jian Yang

Bruce S Dunn

Heather D Maynard

Otto O Yang

Linda M Liau

Jan Mrazek

Oliver Karl Foellmer

Janina Jiang

Chris M Weithoff

Raval-Fernandes Sujna

Daniel Buehler

Esther Hui-Jen Lan

Isaac Yang

Cheryl Champion

A sol-gel vault which comprises a complex between a vault particle and a sol-gel. The vault particle comprises one or more one or more passenger molecules. At least one of the one or more passenger molecules is an mINT passenger molecule. At least one of the one or more passenger molecules is a protein. At least one of the one or more passenger molecules is an enzyme. The sol-gel is a silica-based sol-gel.

Sol-gel vaults and methods of making and using thereof

The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.

Vault complexes for cytokine delivery

Disclosed herein are methods and compositions for making vault particles in yeast hosts and yeast vaults produced therefrom.

Methods and compositions for making vault particles in yeast

Disclosed herein are compositions comprising HIV peptide vaults, which are vault particles comprising complexes of MVP proteins and one or more HIV peptides bound or genetically linked to one or more MVP proteins or packaged within the internal cavities of the vault particles and methods of using thereof.

HIV peptide vaults and methods of making and using thereof

The invention relates to compositions of vault complexes for use as delivery agents for hydrophobic and/or aqueous insoluble therapeutic compounds. In one aspect, provided herein is a vault complex comprising a modified major vault protein (MVP), wherein the modified major vault protein comprises a fusion peptide, wherein said fusion peptide is fused to the N-terminus of the major vault protein, and wherein said peptide provides enhanced sequestering of a hydrophobic and/or aqueous insoluble therapeutic compound within the vault complex.

Vaults engineered for hydrophobic drug delivery

The invention relates to compositions of vault complexes for use as adjuvants for stimulating a cellular immune response to an antigen, for example a tumor antigen, and methods of using the vault complexes in the treatment of diseases, such as cancer.

Vault immunotherapy

The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.

Vault complexes

Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.

Vault compositions for immunization

Vault complexes for facilitating biomolecule delivery

A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like particle. A method of preventing damage by one or more than one substance to an organism, to a specific tissue, to specific cells, or to an environmental medium, by sequestering the one or more than one substance within a vault-like particle. A method of delivering one or more than one substance or a sensor to an organism, to a specific tissue, to specific cells, or to an environmental medium. According to another embodiment of the present invention, there is provided a method of making vault-like particles, and making vault-like particles comprising one or more than one substance, or one or more than one sensor.

Vault and vault like carrier molecules

Vault and vault-like carrier molecules

Growing community of inventors

Tarzana, CA, United States of America

Leonard H Rome