Volastra Therapeutics, Inc.

Leon Van Berkom

Sarah Bettigole

Piotr Nieczypor

Michael Su

Rutger Folmer

Prashanna Vijayachandran

Gydo Van Der Heijden

The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to triazolopyrimidine and imidazolopyrimidine inhibitors of ENPP1 and methods of their use for treating disease mediated by ENPP1.

Heterocyclic inhibitors of ENPP1

The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to sulfoximine-based inhibitors of ENPP1 and methods of their use for treating disease mediated by ENPP1.

Imino sulfanone inhibitors of ENPP1

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Nijmegen, Netherlands

Leon Van Berkom