Other

Vasocor, Inc.

Tri Fund Research Corporation

Leon T Snyder

John N Hoffman

Jeffrey K Raines

Frank A Scarfone

James L Reuss

George V Campen

George H Yates

The method of calibrating includes selecting discrete levels of cuff pressure and placing the artery under study at those discrete levels of induced pressure with a closed pneumatic cuff system, substantially continually sensing cuff pressures at each discrete level and thereby sensing blood volume change through the artery, electronically determining when a certain number of representative blood volume change signals are substantially equivalent, changing the volume in the closed pneumatic system at each discrete cuff pressure by a predetermined volumetric amount after determining substantial equivalency, and, correcting the blood volume change signal based upon the signals detected during the volume change of the closed pneumatic cuff system. The calibration device includes, in one embodiment, a controllable pneumatic pump, a pressure sensor, a computerized device for determining when a representative number of blood volume change signals (based on the pressure sensor signals) are substantially similar and thereafter generating a calibration trigger signal. The calibration system also includes a device which changes the volume in the closed pneumatic system by a predetermined calibrated volumetric amount upon application of the calibration trigger signal. This volume changing device may be a reciprocating piston.

Calibration of segmental blood volume changes in arteries and veins for

The method of calibrating the volume plethysmograph designed to detect atherosclerosis includes selecting discrete levels of cuff pressure and placing the artery under study at those discrete levels of induced pressure with a closed pneumatic cuff system, substantially continually sensing cuff pressures at each discrete level and thereby sensing blood volume change through the artery, electronically determining when a certain number of representative blood volume change signals are substantially equivalent, changing the volume in the closed pneumatic system at each discrete cuff pressure by a predetermined volumetric amount after determining substantial equivalency, electronically generating a calibration signal or factor at each discrete cuff pressure based upon changed blood volume change signal and, correcting the blood volume change representative signal based upon the calibration signal or factor at each discrete level of pressure. The calibration device includes, in one embodiment, a controllable pneumatic pump, a pressure sensor, a computerized device for determining when a representative number of blood volume change signals (based on the pressure sensor signals) are substantially similar and thereafter generating a calibration trigger signal. The calibration system also includes a device which changes the volume in the closed pneumatic system by a predetermined calibrated amount in the presence of the calibration trigger signal. This volume changing device may be a series of valves coupled by a chamber having a known volumetric size, a positive displacement pump driven by a stepper motor or a reciprocating piston.

Calibration of segmental blood volume changes in arteries and veins

The method of calibrating includes selecting discrete levels of cuff pressure and placing the artery or vein under study under discrete levels of induced pressure with a closed pneumatic system contained by the pressure cuff, substantially continually sensing cuff pressures at each discrete level and thereby sensing blood volume change through the artery, electronically determining when a certain number of representative time-based blood volume change signals are substantially equivalent, changing the volume in the closed pneumatic system at each discrete cuff pressure by a pre-determined volumetric amount after determining substantial equivalency, electronically generating a calibration signal at each discrete cuff pressure based upon the calibrated volume change and, correcting the blood volume representative signal based upon the calibration signal at each discrete level of pressure. The calibration device includes, in one embodiment, a controllable pneumatic pump, a pressure sensor, a computerized device for determining when a representative number of blood volume change signals (based on the pressure sensor signals) are substantially similar and thereafter generating a calibration signal. The calibration system also includes a device which changes the volume in the closed pneumatic system by a predetermined calibrated amount in the presence of the calibration trigger signal. This volume changing device may be a series of valves coupled by a chamber having a known volumetric size or a positive displacement pump driven by a stepper motor. The calibration system also includes a computerized device for correcting representative blood volume change signals based on the pressure signals at each discrete level of cuff pressure as corrected by the calibration signals represented by detected pressure signals obtained substantially simultaneously with the change of the volume at each discrete level of cuff pressure.

Calibration of segmental blood volume charges in arteries and veins for

The method of calibrating includes selecting discrete levels of cuff pressure and placing the artery or vein under study under discrete levels of induced pressure with a closed pneumatic system contained by the pressure cuff, substantially continually sensing cuff pressures at each discrete level and thereby sensing blood volume change through the artery, electronically determining when a certain number of representative time-based blood volume change signals are substantially equivalent, changing the volume in the closed pneumatic system at each discrete cuff pressure by a pre-determined volumetric amount after determining substantial equivalency, electronically generating a calibration signal at each discrete cuff pressure based upon the calibrated volume change and, correcting the blood volume representative signal based upon the calibration signal at each discrete level of pressure. The calibration device includes, in one embodiment, a controllable pneumatic pump, a pressure sensor, a computerized device for determining when a representative number of blood volume change signals (based on the pressure sensor signals) are substantially similar and thereafter generating a calibration signal. The calibration system also includes a device which changes the volume in the closed pneumatic system by a pre-determined calibrated amount in the presence of the calibration trigger signal. This volume changing device may be a series of valves coupled by a chamber having a known volumetric size or a positive displacement pump driven by a stepper motor. The calibration system also includes a computerized device for correcting representative blood volume change signals based on the pressure signals at each discrete level of cuff pressure as corrected by the calibration signals represented by detected pressure signals obtained substantially simultaneously with the change of the volume at each discrete level of cuff pressure.

Calibration of segmental blood changes in arteries and veins during

The ventilation monitor of this invention includes a plurality of discrete sensors and a plurality of independent channels for processing the input signals from each of the discrete sensors. The principle category of sensor used in conjunction with this ventilation monitor is capable of the reception of information associated with breathing and cardiovascular movement. A second category of the sensor used in conjunction with this ventilation monitor is capable of the reception of audible sounds associated with breathing. Each of the individual input signals from these sensors is initially verified as being indicative of the sensation being monitored and, thereafter, compared in real time with one another and criteria stored within a microprocessor. The purpose of the comparison is to verify a normal breathing pattern and signal an alarm when the breathing pattern is abnormal. The ventilation monitor is also provided with means to dynamically adjust the gain and frequency response of each channel to accommodate changes in the monitored subject's position and physiological states.

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Boca Raton, FL, United States of America

Leon T Snyder