Rhone-Poulenc S.a.

Leon Ninet

Jean Preud'Homme

Sylvie Pinnert

Denise Mancy

Preud'homme, Jean

The invention provides the novel antibiotic known as daunorubicin (13057 RP) which has a powerful anti-cancer effect and is also an anti-bacterial agent. This antibiotic is a constituent of a mixture of three antibiotics, called 9865 R.P., produced by aerobic culture of one of the strains of Streptomyces, NRRL 3046 and 3045.

Antibiotic daunorubicin and its preparation

This invention relates to antibiotics designated 9865 RP, and its three constituents, hereinafter designated 13057 RP, 13213 RP and 13330 RP and their preparation.

Antibiotics and their preparation

The antibiotic daunorubicin is prepared by aerobically cultivating the microorganism Streptomyces griseus, var. rubidofaciens, DS 32,041 (NRRL 3383), or a daunorubicin-producing mutant thereof, using an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic substances, and separating daunorubicin formed during the culture.

Process for the preparation of daunorubicin by cultivating a

The new antibiotic designated 19,402 R.P. - an acid - is obtained by the cultivation of the microorganism ' Streptomyces 6227' or 'Streptomyces peruviensis' NRRL 2757, the characteristics of which are described in British Patent No. 846,801. The antibiotic and its alkali metal salts are particularly active against gram-positive microorganisms.

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Paris, France

Leon Ninet