Ucb Societe Anonyme

Recherche Et Industrie Therapeutiques (r.i.t.)

Leon Ghosez

Eric Cossement

Robert Biname

Guy Rossey

Freddy Didderen

N-benzyl-2,2-dimethoxy-acetamides having the formula ##STR1## and processes for preparing the same. These acetamides are useful for the production of 2H-3-isoquinolones by acid cyclization and said 2H-3-isoquinolones are in turn useful as starting materials inter alia in the synthesis of 1,4-dihydro-1,4-etheno-isoquinolin-3(2H)ones, which are valuable chemotherapeutic agents as disclosed in U.S. Pat. No. 3,781,436.

N-benzyl-2,2-dimethoxy-acetamides

The invention relates to the stereoisomers of novel cyclopentene derivatives and to the preparation thereof. The cyclopentene derivatives are obtained by cycloaddition reaction between cyclopentadiene and a mono-or bis-thioalkyl (or aryl) ketene and reaction between the obtained product and a nucleophile agent. The compounds of the invention are intermediate products valuable for the preparation of different compounds, among which compounds of the prostaglandin type.

Growing community of inventors

Heverlee, Belgium

Leon Ghosez