Research Against Cancer, Inc.

Other

Dow Corning Corporation

Leon C Parks

Eldon E Frisch

A process of hyperthermic treatment of a patient which comprises the steps of establishing a sterile extracorporeal flow path for blood having an inlet, an outlet and a temperature control zone therebetween, establishing communication of the flow path inlet with the patient's bloodstream so that blood can be supplied to the extracorporeal flow path without adversely affecting the blood circulation in the area from which the blood is withdrawn, establishing communication of the flow path outlet with the patient's bloodstream so that blood is returned to the bloodstream in such a way as to be distributed systemically, pumping blood withdrawn from the patient's bloodstream through the temperature control zone at a controlled rate of at least approximately 1 liter per minute and returning the same to the patient's bloodstream to be distributed systemically, controlling the temperature of the blood flowing through the temperature control zone for an initial period during which the temperature level of the blood within the zone is raised without subjecting the same to localized temperatures in excess of approximately 45.degree. C. so that the systemic distribution of the returned blood gradually increases the core temperature of the patient's body to a generally stable temperature condition at a level of approximately 41.5.degree. C. but not higher than approximately 42.5.degree. C., and maintaining control of the temperature of the blood flowing through the temperature control zone at the generally stable temperature for a second time period sufficient to effect the desired treatment and apparatus for carrying out the method.

Subcutaneous implant useful in effecting hyperthermic treatment

Apparatus for effecting hyperthermic treatment

An improvement in the implantable shunt device of the type disclosed in U.S. Pat. No. 4,181,132 wherein each valving slit within the elastomeric body of the shunt is formed by a flattened sleeve of woven vascular prosthesis material presenting opposed interior surfaces interengaged when the valving slit is in a closed condition and spaced apart when the valving slit is in an open condition. The opposed surfaces of the sleeve are formed by a material having a coefficient of friction with respect to the material of the cannula insertable therethrough less than that of the elastomeric material of the body. A separate yieldable bias operable in addition to the bias provided by the elastomeric material of the body is provided for yieldably biasing the opposed surfaces of the flattened sleeve into sealed relation when in the closed interengaged condition and into sealed relation to the exterior periphery of the portion of the cannula extending therethrough when in the open spaced apart condition. The additional bias is provided by filling under pressure opposed cavities in the elastomeric body with a yieldable material so located with respect to the flattened sleeve as to transmit the pressure thereof as the additional bias of the opposed surfaces into sealed relation when in the closed interengaged condition and into sealed relation with the exterior periphery of the cannula when in the open spaced apart condition.

Valving slit construction and cooperating assembly for penetrating the

An improvement in a method of treating cancer by systemic hyperthermia which comprises measuring the patient's core body temperature in the bladder and controlling the inducement of systemic hyperthermia in accordance with the bladder temperature measured.

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Baltimore, MD, United States of America

Leon C Parks