G.d. Searle & Company

Pfizer Corporation

Pharmacia Corporation

Pharmacia Corporation (of Pfizer, Inc.)

Leo J Letendre

Sastry A Kunda

John S Ng

Bernhard Erb

Yuen-Lung L Sing

Joseph J Wieczorek

Mark John Pozzo

Chin Liu

Edward E Yonan

Jon P Lawson

Dennis K Anderson

Ping T Wang

Julio A Baez

Gennaro Mucciariello

Fortunato Vanzanella

Amarnauth Shastrie Prashad

Richard M Weier

Thomas R Kowar

Robert Wayne Dugger

Tao He

Wenge Wang

Xiaotian Zhong

Ronald William Kriz

Henry T Gaud

George H Klemm

Cynthia Snoddy

Chunchun Zhang

Vimalkumar Babubhai Patel

Will Somers

Gary A De Crescenzo

An antibody production process in mammalian cells in which engineered unpaired cysteine residues are post-translationally modified and capped with particular chemical entities, which capped antibodies are well suited to further site-specific conjugation steps to form antibody-drug conjugates (ADCs) or protein drug conjugates; ADCs produced using these capped antibodies including in particular ADCs formed by the selective reduction of the capped antibodies' cysteine residues, and ADCs formed using chemical handles such as aldehyde/azide/alkyne biorthogonal groups, which permit additional drug conjugation chemistry; and uncapped antibodies produced by cells in low cysteine, cysteine and glutathione media, and ADCs produced via direct conjugation to these uncapped antibodies.

Capped and uncapped antibody cysteines, and their use in antibody-drug conjugation

The present invention relates to intermediates of Formula I and to methods of synthesizing and purifying calicheamicin derivatives.

Intermediates and methods for synthesizing calicheamicin derivatives

A process for the qualitative preparation of 3-haloalkyl-1H-pyrazoles suitable for efficient, high payload commercial application.

Synthesis of diaryl pyrazoles

Multiple novel keto-substituted intermediates are provided for the synthesis of epoxymexrenone, useful as an Aldosterone Receptor Antagonist.

Keto-substituted steroid compounds

Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.

Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein:

Process for preparation of 9, 11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein: &#x2014;A&#x2014;A&#x2014;, &#x2014;B&#x2014;B&#x2014;, R, R, Rand Rare as defined in the specification.

Processes for the preparation of 4,5-dihydro-5,7-lactone steroid compounds are provided.

Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein

Process for preparation of 9,11-epoxy steroids and intermediates useful therein

5&bgr;-cyano-substituted steroid compounds

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Manchester, MO, United States of America

Leo J Letendre