Ab Kabi

Kabivitrum Ab

Lennart E Karlsson

Ferenc Merenyi

Gunnar Hanshoff

Pinchas Moses

Carl Magnus Svahn

Aake N Joensson

Novel antifibrinolytically active compounds of the formula ##STR1## and therapeutically acceptable salt thereof, wherein

Antifibrinolytically active derivatives of tranexamic acid

New compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 each independently represent an alkyl group containing 1 to 4 carbon atoms, or an alkoxy group containing 1 to 3 carbon atoms, or halogen, R.sup.3 represents hydrogen, halogen, an alkyl group containing 1 to 4 carbon atoms, an alkoxy group containing 1 to 3 carbon atoms, an amino group or a nitro group, A represents ##STR2## which is bonded to the benzene ring by its sulphur or nitrogen atom and in which R.sup.4 is hydrogen or an alkyl group containing 1 to 4 carbon atoms; together with salts thereof with physiologically acceptable acids and, when R.sup.4 is hydrogen, with physiologically acceptable bases are described. The compounds are of use in inhibiting thrombosis formation, in treating thrombosis and in fibronolytic therapy. Various methods of producing the new compounds are described involving the building up of the --A--CH.sub.2 --CH.sub.2 --S--CH.sub.2 CH.sub.2 NH.sub.2 side chain from aromatic precursors having an incomplete side chain or by introducing at least one of the R.sup.1, R.sup.2 or R.sup.3 substituents into a precursor lacking that substituent or from an amino-protected precursor.

Anti-thrombotic N-alkylthioakylamino benzenesulfonamides

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Vaellingby, Sweden

Lennart E Karlsson