Coloplast A/s

Lene Karin Jespersen

Hanne Everland

Brian Nielsen

Lene Feldskov Nielsen

Peter Sylvest Nielsen

Jakob Vange

Khadija Schwach-Abdellaoui

The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O&#x2014;(CHRCHRO)&#x2014;B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [&#x2014;CH(CH)&#x2014;COO&#x2014;] and (ii) glycolide units [&#x2014;CH&#x2014;COO&#x2014;] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C-alkyl or hydroxy protecting groups, one of Rand Ris hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [&#x2014;(CHRCHRO)&#x2014;] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.

Degradable hydrophilic block copolymers with improved biocompatibility for soft tissue regeneration

We add discontinuous regions of Extra Cellular Matrix (ECM) to a biodegradable scaffold. Hereby it is possible to combine the range of physical properties the scaffold can offer with the reconstructive properties of the ECM. The optimal amount of discrete ECM material for each application is disclosed and this concentration is equally distributed in the dressing hence avoiding unnecessary high concentrations of ECM. In addition to the effect of the ECM, the porous structure of the base material provides the cells with a structure for in-growth.

Biodegradable scaffold with ECM material

Growing community of inventors

Fredensborg, Denmark

Lene Karin Jespersen