Ibis Biosciences, Inc.

Lendell Cummins

Steven A Hofstadler

David J Ecker

Mark W Eshoo

Gerard J Gundling

Stanley T Motley

Thomas Laffler

Todd P Michael

Danny M Chou

Cristina A Ivy

The invention provides methods for extraction of fungal (e.g., yeast spp., filamentous fungal spp.) nucleic acid (e.g., DNA, RNA) from a sample (e.g., be human or veterinary clinical or research samples, agricultural samples, agricultural commodity samples, food products, or environmental samples). In some embodiments, the present invention provides enhanced nucleic acid extraction from samples comprising fungal cell(s) wherein enzymatic (e.g., lysostaphin treatment, lyticase treatment) sample treatment is performed in combination with mechanical (e.g., bead beating) sample treatment.

Fungal nucleic acid extraction

Provided herein are compositions and methods for the alteration of neuronal methylation by synthetic piRNAs or by alteration of piRNA function. Such alterations find use in the regulation and control of neural gene expression and concomitant neural functions. Further provided herein are systems and methods for the identification of target sites for regulation by piRNAs.

Alteration of neuronal gene expression by synthetic piRNAs and by alteration of piRNA function

The present invention provides a method for rapid solution capture purification of nucleic acids for subsequent analysis by electrospray mass spectrometry which is efficient and cost-effective relative to existing methods. The present invention also provides kits useful for practicing rapid solution capture of nucleic acids so that purified samples are in condition for analysis by electrospray mass spectrometry.

Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture

Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture

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San Diego, CA, United States of America

Lendell Cummins