University of California

University of Rhode Island Research Foundation

Genyous Biomed International Inc.

Lena Gerwick

William H Gerwick

David C Rowley

Jennifer Smith

James Dao

Francisco Villa

Leslie Wilson

Hyuakjae Choi

Jeffery Dao

MaryAnn Jordan

Emin Oroudjev

Jeffrey Dao

William Gerwick

Judy Mikovits

Tatiana Okouneva

Allen Chuan Gao

The invention provides novel compositions based on a structure designated as 'Honaucin A', including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.

Anti-inflammatory and quorum sensing inhibition compounds and methods of making and using them

Growing community of inventors

La Jolla, CA, United States of America

Lena Gerwick