Illumina Corporation

Lena Christiansen

Frank J Steemers

Eric Hans Vermaas

Rigo Pantoja

Dmitry K Pokholok

Fan Zhang

Ramesh Ramji

Steven Norberg

Gary Schroth

Jerushah Thomas

Weihua Chang

Megan Chu

Patrizia Iavicoli

Jeffrey Brodin

The invention relates to a system and methods for enhancing access to nuclear informational molecules, such as DNA, RNA, and proteins, by analytical biomolecules, such as transposome complexes, by treating nuclei with a nuclear permeability enhancer, and to methods of using nuclear membrane, cell membrane, and external compartmentalization approaches as contiguity preserving elements.

Analysis system for orthogonal access to and tagging of biomolecules in cellular compartments

Embodiments of systems, methods, and compositions provided herein relate to assays for selectively controlling enzymatic reactions. Some embodiments relate to methods of inhibiting, reducing, or eliminating secondary DNA (such as mitochondrial DNA) sequencing reads from open chromatic sequencing, whole genome sequencing, or targeted sequencing.

Methods and means for preparing a library for sequencing

Embodiments of systems, methods, and compositions provided herein relate to hollow beads encapsulating single cells. Some embodiments include performing multiple co-assays on a single cell encapsulated within a hollow bead, including nucleic acid sequencing, preparing nucleic acid libraries, determining methylation status, identifying genomic variants, or protein analysis.

Contiguity particle formation and methods of use

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San Diego, CA, United States of America

Lena Christiansen