Other

City College of New York

Leming M Wang

Robert R Alfano

Yury Budansky

Ping-Pei Ho

Guichen C Tang

Xiangchun Liang

Asima Pradhan

Feng Liu

Ping Pei Ho

Quan-Zhen Wang

Bidyut B Das

Bidyut Baran Das

Pierre A Galland

A method for detecting the presence of one or more calcifications within a portion of a turbid medium, such as a breast tissue. According to one aspect, the method involves illuminating at least a portion of the turbid medium with light, whereby light emerges from the turbid medium consisting of a ballistic component, a snake-like component and a diffuse component, temporally and/or spatially gating the emergent light to preferentially pass the ballistic and/or snake-like components, using the temporally and/or spatially gated light to form an image of the illuminated portion of the turbid medium, and examining the image for the presence of one or more calcifications. Wavelength difference images may also be used to highlight tumors and calcification regions. The foregoing method may be used to form optical images of breast tissues, with the presence in such images of calcifications suggestive of cancer being used to identify the corresponding breast tissues as good candidates for biopsy and screening for tumors.

Optical imaging of breast tissues to enable the detection therein of

A system for imaging an object in or behind a highly scattering medium includes a light source for illuminating the highly scattering medium with a beam of light. The light emerging form the highly scattering medium consists of a ballistic component, snake-like component and a diffuse component. A 4F Fourier imaging system including a Fourier spatial filter located at 2F is used to form a time gated image of the emerging light, the time gated image consisting primarily of the ballistic component and the snake-like component.

Ultrafast optical imaging of objects in or behind scattering media

A method for determining if tissue is malignant as opposed to non-malignant (i.e., benign tumor tissue, benign tissue, or normal tissue). In one embodiment, the method comprises irradiating a human breast tissue sample with light at a wavelength of about 310 nm and measuring the time-resolved fluorescence emitted therefrom at about 340 nm. The time-resolved fluorescence profile is then compared to similar profiles obtained from known malignant and non-malignant human breast tissues. By fitting the profiles to the formula I(t)=A.sub.1 e.sup.(-t/.tau. 1.sup.) +A.sub.2 e.sup.(-t/.tau. 2.sup.), one can quantify the differences between tissues of various conditions. For example, non-malignant human breast tissues exhibit a slow component (.tau..sub.2) which is less than 1.6 ns whereas malignant human breast tissues exhibit a slow component (.tau..sub.2) which is greater than 1.6 ns. In addition, non-malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is greater than 0.85 whereas malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is less than 0.6. This technique can be used with different excitation and/or emission wavelengths, and can be applied to the detection of malignancies (or other abnormal states) in tissues other than human breast tissue.

Method for determining if tissue is malignant as opposed to

A system for imaging an object in or behind a highly scattering medium includes a laser for illuminating the highly scattering medium with a beam of light. The light emerging from the highly scattering medium consists of a ballistic component, a snake-like component and a diffuse component. A 4F Fourier imaging system with a Kerr gate located at 2F is used to form a time-space gated image of the emerging light, the time-space gated image consisting primarily of the ballistic component and the snake-like component.

Ultrafast optical imaging of objects in a scattering medium

A method for determining if tissue is malignant as opposed to non-malignant (i.e., benign tumor tissue, benign tissue, or normal tissue), In one embodiment, the method comprises irradiating a human breast tissue sample with light at a wavelength of about 310 nm and measuring the time-resolved fluorescence emitted therefrom at about 340 nm. The time-resolved fluorescence profile is then compared to similar profiles obtained from known malignant and non-malignant human breast tissues. By fitting the profiles to the formula I(t)=A.sub.1 e(-t/.tau..sub.1)+A.sub.2 e(-t/.tau..sub.2) one can quantify the differences between tissues of various conditions. For example, non-malignant human breast tissues exhibit a slow component (.tau..sub.2) which is less than 1.6 ns whereas malignant human breast tissues exhibit a slow component (.tau..sub.2) which is greater than 1.6 ns. In addition, non-malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is greater than 0.85 whereas malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is less than 0.6. This technique can be used with different excitation and/or emission wavelengths, and can be applied to the detection of malignancies (or other abnormal states) in tissues other than human breast tissue.

Growing community of inventors

Flushing, NY, United States of America

Leming M Wang