Ab Kabi

Pharmacia Aktiebolag

Lembit Mikiver

Pinchas Moses

Nils A Jonsson

Nils Ake Jonsson

Bengt Ang Sparf

Aake N Joensson

Gunilla Glas

Lisbet Nilvebrant

Bengt A Sparf

Tomas G Kempe

##STR1## Novel 3,3-diphenylpropylamines of formula (I) wherein R.sup.1 signifies hydrogen or methyl, R.sup.2, R.sup.3 and R.sup.4 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphanoyl or halogen, and X represents a tertiary amino group -NR.sup.5, R.sup.6, wherein R.sup.5 and R.sup.6 signify non-aromatic hydrocarbyl groups, which may be the same or different and which together contain at least three carbon atoms, and which may form a ring together with the amine nitrogen, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers, their use as drugs, especially as anticholinergic agents, their use for preparing an anticholinergic drug, pharmaceutical compositions containing the novel amines, and methods for preparing the same.

3,3-diphenylpropylamines and pharmaceutical compositions thereof

New geminally disubstituted indenes are of general formula I ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or R.sup.1 and R.sup.2 together form a direct bond or an alkylene group --(CH.sub.2).sub.n --, in which n is an integer from 1 to 4, R.sup.3 is hydrogen, C.sub.1-3 -alkoxy or halogen, and each of R.sup.4 and R.sup.5 is hydrogen or C.sub.1-4 -lower alkyl, or R.sup.4 and R.sup.5 together form an alkylene group --(CH.sub.2).sub.m --, in which m is an integer from 3 to 6; and the corresponding amine oxides, quaternary ammonium compounds and salts with physiologically acceptable acids. The indenes find use in treating incontinence, as a mucous membrane decongestant, as a blood pressure reducing agent, as vasocostrictor or as an anti-reserpine agent. The indenes may be prepared by processes known per se involving

Geminally disubstituted indene derivatives

New pharmacodynamically active nitrogen-containing heterocyclic compounds of the general formula ##STR1## as well as methods of preparing the same; and pharmacodynamical compositions containing the same, preferably for treating psychiatric and psychosomatic diseases.

Derivatives of substituted indoline lactans with effect on the central

Derivatives of substituted isoindolines with effect on the central

New pharmacodynamically active nitrogen containing heterocyclic compounds of the general formula ##SPC1## As well as methods of preparing the same; and Pharmacodynamical compositions containing the same, preferrably for treating psychiatric and psychosomatic diseases.

Derivatives of substituted isoquinoline 1,3-diones

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Jarna, Sweden

Lembit Mikiver