Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Lelle Vasvari

Istvan Hermecz

Agnes Horvath

Judit Sipos

Peter Ritli

Aniko Pajor

Geza Kereszturi

Jozsef Knoll

Maria Balogh

Zoltan Meszaros

Katalin Marmarosi

Gabor Kovacs

Sandor Virag

Agoston David

Zoltan Meszaros, Deceased

Gyula Sebestyen

Zoltan Kapui

Laszlo Tardos

Peter Szentmiklosi

Gabor Horvath

Klara Gyires

Peter Dvortsak

Maria Halogh

Marie Balogh

Ilona Papp

Peter Szentmiklosy

Piroska Simon

3-(substituted tetrazolyl)-4-oxo-4H-pyrido-[1,2-a]pyrimidines, salts

The invention relates to a new process for the preparation of antibacterial compounds of the Formula I ##STR1## wherein R.sup.1 stands for phenyl substituted by 1 or 2 halogen atoms;

Process for the preparation of quinoline carboxylic acid derivatives

The invention relates to a new process for the preparation of compounds of the general Formula I ##STR1## wherein R stands for piperazinyl, 4-methyl-piperazinyl or 4-ethyl-piperazinyl group and pharmaceutically acceptable salts thereof which comprises reacting a compound of the general Formula II ##STR2## wherein R.sup.1 and R.sup.2 stand for halogen, for an aliphatic acyloxy group containing 2 to 6 carbon atoms and optionally substituted by halogen, or for an aromatic acyloxy group containing 7 to 11 carbon atoms with a piperazine derivative of the general Formula III ##STR3## wherein R.sup.3 stands for hydrogen, methyl or ethyl or a salt thereof and subjecting the compound of the general Formula IV ##STR4## thus obtained wherein R, R.sup.1 and R.sup.2 are as stated above to hydrolysis after or without isolation and if desired converting the compound of the general Formula I thus obtained into a salt thereof or setting free the same from its salt. The compounds of the general Formula I are known antibacterial agents.

Process for the preparation of quinoline carboxylic acids

Baron chelates of quinoline carboxylic acids

Quinoline carboxylic acid boric acid anhydrides

Boric anhydrides of

Norfloxacin intermediate

New compounds of the following formula are disclosed:

Condensed pyrimidines

An optically active or racemic fused pyrimidine derivative of the formula I ##STR1## has pharmaceutical activity in decreasing serum lipids, cholesterol deposits and, in general, against atherosclerosis.

Fused pyrimidine derivatives and antiatherosclerotic methods of

Pyrida-(1,2A)-pyrimidine-derivatives and a process for preparing these compounds are disclosed. These compounds possess analgesic, anti-inflammatory, and anti-pyretic properties as well as the ability to depress the central nervous system.

3-(Ethoxycarbonyl-methyl)-6-methyl-4-oxo-6,7,8,9-tet

The present invention is concerned with the preparation of chemical intermediates, namely, beta-amino-acrylic acid ester derivatives of nitrogen heterocycles, i.e. pyridine, quinoline, quinoxaline, pyrazine, pyrimidine and the like. Said intermediates are cyclized to form pyrido-pyrimidine type final products possessing analgesic activity.

Heterocyclic-amino-acrylic acid derivatives

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Budapest, Hungary

Lelle Vasvari