Cornell University

Leland E Carmichael

Max J Appel

Allen Gruenberg

Fredric W Scott

Lisle W George

Douglas D McGregor

The invention is directed to attenuated canine parvovirus (CPV) strains which may be used as a veterinary vaccine against CPV disease. The invention is further directed to a virus stock generated from a genomic DNA clone of the attenuated CPV strain which is used as a veterinary vaccine and is able to confer protective immunity to dogs against challenge with virulent CPV. Methods are given for the production of an attenuated CPV virus from a cloned CPV genome which may be used as a veterinary vaccine.

Attenuated canine parvovirus vaccine

The invention is directed to a novel attenuated canine parvovirus (CPV) strain which may be used as a veterinary vaccine against CPV disease. The invention is further directed to a virus stock generated from a genomic DNA clone of the attenuated CPV strain which is used as a veterinary vaccine and is able to confer protective immunity to dogs against challenge with virulent CPV. Methods are given for the production of an attenuated CPV virus from a cloned CPV genome which may be used as a veterinary vaccine.

A safe, efficacious vaccine for protecting dogs against infection caused by canine parvovirus is produced by prolonged serial passages in non-oncogenic cell lines. One embodiment includes the use of sub-optimal temperatures (below that normal for the dog) during passaging.

Modified living canine parvovirus vaccine

This invention relates to a vaccine against Canine Herpesvirus from a newly isolated small-plaque variant of Canine Herpesvirus, and to a method for producing small-plaque variant reduced pathogenicity canine herpesvirus.

Small-plaque variant canine herpesvirus vaccine

The present invention relates to the method of protecting dogs against canine parvoviruses. More specifically, the present invention relates to a method of producing an inactivated (killed) canine parvoviral vaccine from a native virulent strain of CPV for use as a vaccine in dogs against disease caused by virulent canine parvoviruses.

Canine parvovirus vaccine

A vaccine against disease caused by canine parvoviruses (CPV) is produced using a modified live (attenuated) or chemically inactivated feline panleukopenia virus vaccine.

Heterotypic canine parvovirus vaccine

This invention relates to the use of Brucella ovis antigens to diagnose the presence of Brucella canis in an animal. B. canis is the causative agent of canine brucellosis. Further, this invention relates to a plate test where B. ovis antigens are employed for rapid accurate determination of B. canis.

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Ithaca, NY, United States of America

Leland E Carmichael