Axim Biotechnologies, Inc.

Apirx Pharmaceutical USA, LLC

Lekhram Changoer

George Evgeniyevich Anastassov

Cornelis Herman Michel Van Der Loo

Erik Keller

Philippus Anne Van Damme

George Anastassov

A method to treat the skin condition psoriasis is described in this invention. The method comprises topical application of a composition containing cannabinoids, in particular cannabidiol and cannabigerol at a concentration of 3%-20% by weight of the composition. The topical application is applied at least twice daily for six weeks.

Method to treat psoriasis

This application discloses oral care compositions comprising cannabinoids, preferably cannabidiol and/or cannabigerol. The oral care composition disclosed in this application may be a tooth paste, a tooth powder, or a mouthwash solution. The oral care composition may be used to treat oral infectious disease, including periimplantitis, periodontitis, oral mucositis, and dental pain.

Oral care composition comprising cannabinoids

A method to treat the skin condition vitiligo is described in this invention. The method comprises topical application of a composition containing cannabinoids, in particular cannabidiol and cannabigerol, at a concentration of 3%-20% by weight of the composition onto the affected skin area of a subject in need thereof. Application may be twice (2) daily for about six (6) weeks. Cannabidiol and cannabigerol may be sourced naturally or synthetically.

Method to treat vitiligo

&#x394;-THC carboxylic acid is extracted fromflowers using a first organic solvent, then separated using a second aqueous solvent. &#x394;-THC carboxylic acid is converted to &#x394;-THC carboxylic salt before being extracted by a third organic solvent and converted back to &#x394;-THC carboxylic acid. Using a solvent swap, &#x394;-THC carboxylic acid is decarboxylated and extracted again with an organic solvent prior to purification to give &#x394;-THC.

Process to extract and purify delta-9-tetrahydrocannabinol

This invention discloses anti-bacterial and anti-fungal compositions in spray form, in cream form, in liquid form, and in powder form. The anti-bacterial and anti-fungal compositions comprise cannabinoids, specifically cannabidiol, cannabigerol, tetrahydrocannabinol, tetracannabidivarin, and/or cannabidivarin for anti-bacterial and anti-fungal activities. The anti-bacterial and anti-fungal compositions may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.

Anti-microbial compositions comprising cannabinoids

This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.

Suppositories comprising cannabinoids

A chewing gum composition comprising cannabinoids or derivatives thereof and nicotine in the form of nicotine polacrilex is provided. The chewing gum composition is formulated to provide rapid and controlled release of cannabinoids and nicotine during chewing. Methods to provide tobacco and/orsmoking cessation using the chewing gum composition according to this invention are also provided.

Chewing gum composition comprising cannabinoids and nicotine

Anti-microbial composition comprising cannabinoids

A method to treat the skin condition atopic dermatitis is described in this invention. The method comprises topical application of a composition containing cannabinoids, specifically cannabidiol and cannabigerol at a concentration of 3%-20% by weight of the composition. The method may further comprise administering chewing gum containing cannabinoids such as cannabidiol. Cannabidiol and cannabigerol may be sourced naturally or synthetically.

Method to treat atopic dermatitis

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&#x394;-THC acid is extracted fromflowers using a first organic solvent, then separated using a second aqueous solvent. &#x394;-THC acid is converted to &#x394;-THC carboxylic salt before being extracted by a third organic solvent and converted back to &#x394;-THC carboxylic acid. Using a solvent swap, &#x394;-THC carboxylic acid is decarboxylated and extracted again with an organic solvent prior to purification to give &#x394;-THC.

This invention generally relates to methods of treatment of glaucoma and symptomatic relief of conjunctival inflammation. An ophthalmic solution comprising cannabinoids for the treatment of glaucoma and an ophthalmic solution comprising cannabinoids for these purposes are disclosed. Cannabinoids are selected to achieve the specific purpose of the respective ophthalmic solution.

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Ridderkerk, Netherlands

Lekhram Changoer