Beijing Biosis Healing Biological Technology Co., Ltd.

Leilei Xia

Yanrui Zhao

Wei Zhao

Bo Zhao

Jinhui Zhang

Pengfei Wei

Xuejun Li

Hongquan Wang

Wei Jing

The present disclosure pertains to the field of biomedical materials, and in particular relates to a medical hydrogel, a preparation method and uses thereof, and a kit for preparing the medical hydrogel. The medical hydrogel of the present disclosure comprises a hydrogel skeleton, and a chelating agent chelated to the hydrogel skeleton; wherein the hydrogel skeleton comprises a polymer that is formed by the bonding of a polyethylene glycol derivative I having a structure shown in Formula (I) and a polyethylene glycol derivative II having a structure shown in Formula (II) and has multiple 'long arms'. After tannic acid and/or citric acid as a chelating agent chelates with the hydrogel skeleton, a medical hydrogel can be obtained, which has good bacteriostatic properties, mechanical properties, adhesion properties, low swelling properties, and controllable gel formation rate and degradation rate. Moreover, the hydrogel is able to maintain viscosity in a wet state without being affected by body fluids, and it can still ensure effective adhesion and closure of wounds if there is movement or pulsation of the tissue, thus having great clinical application prospects.

Medical hydrogel and preparation method and uses thereof

Disclosed are a biological tissue matrix material, a preparation method therefor and the use thereof in an otological repair material. The biological tissue matrix material comprises an extracellular matrix. The extracellular matrix comprises a collagen fiber, a growth factor and fibronectin. The biological tissue matrix material has a low amount of DNA residue, a low immunogenicity, a high anti-infection ability, and a strong repair capability.

Biological tissue matrix material, preparation method therefor and use thereof in otological repair material

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Beijing, China

Leilei Xia