Dnae Group Holdings Limited

Dna Electronics Limited

Leila Shepherd

Christofer Toumazou

Samuel Reed

Alpesh Patel

Zahid Ansari

Kurt Kolb

Sam Reed

Daniel Morley

Krishna Amin

Ginny Jorgensen

Bhusana Premanode

Bhusana c/o Imperial College Premanode

Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.

Sensing apparatus for amplification and sequencing of template polynucleotides and array for amplification of template polynucleotides

A signal processing circuit includes an ion sensitive field effect transistor, a reference electrode for the ion sensitive field effect transistor, a metal oxide semiconductor transistor having its gate coupled to the reference electrode, and a biasing circuit. The biasing circuit is configured to bias the ion sensitive field effect transistor and the metal oxide semiconductor field effect transistor to operate in a weak inversion region and to provide an output current signal.

Signal processing circuit comprising ion sensitive field effect transistor and method of monitoring a property of a fluid

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London, United Kingdom

Leila Shepherd