Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Les Laboratories Servier

Les Laboratoires Servier

Institut National De La Sante Et De La Recherche Medicale (inserm)

Progastrine Et Cancers S.a R.l.

Leïla Houhou

Dominique Joubert

Frédéric Hollande

Jean-François Floch

Julie Pannequin

Françoise Cailler

Anne-Sophie Dumé

Nejla Erkilic

Mathieu Petremann

Bérénice Framery

The present disclosure provides methods of treating liver cancer and preventing liver cancer recurrence with anti-progastrin antibodies, methods of monitoring treatment efficacy of anti-progastrin therapy for liver cancer, and compositions useful therefore.

Methods and compositions for liver cancer therapy

The present disclosure provides methods and compositions useful for preventing gastrointestinal and/or colorectal cancer in animals, including humans, having pre-cancerous adenomatous polyps. The present disclosure provides compositions comprising anti-PG antibodies suitable for use in the methods of the disclosure. The present disclosure also provides methods and compositions useful for monitoring the efficacy of anti-PG treatment in subjects with pre-cancerous polyps.

Prophylaxis of colorectal and gastrointestinal cancer

The present disclosure is directed to methods of treating pancreatic cancer in subject using cancer with antibodies that specifically bind to progastrin.

Methods for treating pancreatic cancer

The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.

Methods for treating colorectal cancer

The present disclosure is directed to methods of treating and preventing breast cancer or recurrence of breast cancer with compositions comprising anti-progastrin antibodies.

Methods for treating breast cancer

Progastrin levels are determined to diagnose one or more liver pathologies.

Growing community of inventors

Montpellier, France

Leïla Houhou