Chelsea Therapeutics, Inc.

Leif Svenson

Ingela Fritzson

Ulf Vellmar

Ingrid Hallin

Helén Tuvesson Andersson

Compounds of formula (I) are provided, wherein X is CH&#x2550;CH, CHO wherein the oxygen atom is bound to ring B, or OCHwherein the oxygen atom is bound to ring A; Y is hydrogen, straight or branched C1-C6 alkyl or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; and R2 and R3 are the same or different and are selected from F, Cl, Br, CFand OCF. The compounds are useful for the treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection, and malignant neoplasia. Pharmaceutical compositions containing the compounds, methods of using the compounds, and methods for preparing the compounds are also provided.

Anthranilic acid derivatives

Compounds of formula (I) are provided, wherein X is CH&#x2550;CH, CHO wherein the oxygen atom is bound to ring B, or OCHwherein the oxygen atom is bound to ring A; Y is hydrogen, straight or branched C1-C6 alkyl or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; and R2 and R3 are the same or different and are selected from F, Cl, Br, CFand OCF. The compounds are useful for the treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection, and malignant neoplasia. Pharmaceutical compositions comprising the compounds, methods of using the compounds, and methods for preparing the compounds are also provided.

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Rydebäck, Sweden

Leif Svenson