Novo Nordisk A/s

Unilever Plc

Leif No slashedrskov-Lauritsen

Lars Christian Petersen

Kjeld Norris

Fanny Norris

Claus Bregengaard

Niels D Christensen

Viggo Diness

Soren E Bjo Slashedrn

Ole Hvilsted Olsen

Palle Jakobsen

Dorrit A Aaslyng

Sven Hastrup

Sven Branner

Marit Kristiansen

Lars Naerum

Johan Haverkamp

John D Marugg

Maarten Robert Egmond

Eric Casteleijn

Merete Simonsen

Karsten Lundgren

Arnoldus Theodorus Mooren

The present invention relates to (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine and other substituted 2-methylpyrrolidines and their use for the treatment of diabetes.

2-alkylpyrrolidines

The present invention relates to modified subtilisins comprising a mutation in an amino acid sequence of a subtilisin at a position selected from the group consisting of 1, 2, 3, 4, 6, 9, 10, 12, 14, 15, 17, 18, 19, 20, 21, 22, 24, 25, 27, 36, 37, 38, 40, 41, 43, 44, 45, 46, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 75, 76, 77, 78, 79, 87, 89, 91, 94, 97, 98, 99, 100, 101, 103, 104, 105, 106, 107, 108, 109, 112, 113, 115, 116, 117, 118, 120, 126, 128, 129, 130, 131, 133, 134, 136, 137, 140, 141, 143, 144, 145, 146, 155, 156, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 170, 171, 172, 173, 181, 182, 183, 184, 185, 186, 188, 189, 191, 192, 194, 195, 197, 204, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 259, 260, 261, 262, 263, 265, 269, 271, 272 and 275. The present invention also relates to detergent compositions comprising a modified subtilisin of the present invention.

Modified subtilisins and detergent compositions containing same

The present invention relates to methods for producing aprotinin and analogs thereof in yeast, synthetic genes encoding such products, expression vectors and transformed yeast cells. The invention further relates to aprotinin analogs, particularly analogs with increased specific inhibitory activity and/or reduced nephrotoxicity compared to native aprotinin, as well as compositions comprising such analogs.

Aprotinin analogs

Process for preparing aprotinin and aprotinin analogs in yeast cells

Growing community of inventors

K.o slashed.ge, Denmark

Leif No slashedrskov-Lauritsen