Pharmacia Ab

Kabi Pharmacia Ab

Leif G Ahrgren

Lars-Inge Olsson

Martin Haraldsson

Anthony N De Belder

Thomas Berglindh

Hubert Agback

Tomas Malson

G Oran Smedegangrd

Goran Smedegard

Goran Smedegangrd

A compound of the formula Het--NR--SO.sub.2 --Ph.sup.2 --A--Ph.sup.1 (COOH)(OH) and tautomic form, salts, solvates, C.sub.1-6 alkyl esters and pharmaceutical compositions of the compound. Ph.sup.1 and Ph.sup.2 are benzene rings with the proviso that carboxy and hydroxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A is a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl. The invention also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.

N-heterocyclic substituted salicylic acids

Substituted salicylic acids

A compound of the formula Het--NR--SO.sub.2 --Ph.sup.2 --A--Ph.sup.1 (COOH)(OH) and tautomeric form, salts, solvates, C.sub.1-6 alkyl esters and pharmaceutical compositions of the compound. Ph.sup.1 and Ph.sup.2 are benzene rings with the proviso that carboxy and hydroxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A is a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl. The invention also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.

Compounds containing an amino salicylic acid moiety linked to a

A new method for preparation of sulfated polysaccharides by means of pyridine-chlorosulfonic acid reagents. The polysaccharide is before sulfation treated with a reducing agent, e.g. sodium borohydride.

Method for preparation of sulfated polysaccharides by treating the

A shaped article based upon cross-linked, possibly derivatized hyaluronic acid or a salt thereof is characterized in that it has a dry matter content of at least 65 percent by weight and a tensile strength of at least 2 N/cm.sup.2. The shaped article may be prepared by pressure-drying or freeze-drying a corresponding hyaluronic acid gel.

Shaped article and processes for its preparation

The invention relates to a new polymer containing quarternary amino group based on dextran or cross-linked dextran. The quarternary amino groups are of the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3, which may be identical or different, are lower alkyl groups of 1-5 carbon atoms or lower hydroxyalkyl groups of 2-5 carbon atoms and 1-2 hydroxy groups. At most one atom other than carbon and hydrogen is bound to the same carbon atom in the hydroxy alkyl group.

Growing community of inventors

Tierp, Sweden

Leif G Ahrgren