Nitto-denko Corporation

University of Utah Research Foundation

Lei Yu

Sang Van

Gang Zhao

Yasunobu Tanaka

Zheng Hou

Xiaoli Fu

Jian Liu

Yi Jin

Shouping Ji

Yoshiro Niitsu

Kwok Yin Tsang

Chieko Kitaura

Xinghe Wang

Elena Feinstein

Jun Zhang

Wenbin Ying

Joseph E Payne

Igor Mett

Priya Prakash Karmali

Hagar Kalinski

Mohammad Ahmadian

Sharon Avkin-Nachum

Richard P Witte

Victor Knopov

Violetta Akopian

John Gaudette

Hao Bai

Hirokazu Takahashi

Shai Erlich

Elizabeth C Squiers

Zhongling Feng

Yucheng Song

Kenji Matsumoto

Xiaomei Jin

Neda Safarzadeh

Ning Chen

Kenjiro Minomi

Jiadong Zhou

Nitnara Viroonchatapan

Sung Wan Kim

Seiji Nukui

Katsuyuki Okubo

Hai Wang

Chunfeng Yin

Hyun Sik Chae

Keisaku Okada

Sanjib Kumar Das

Fu Chen

Fusheng Du

Nianchun Ma

Chris Castello

Natsuko Kagehisa

Masashi Kamiyama

Jae-Woon Nah

Sharon Avkin-nachum

John A Gaudette

The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.

Lipids for therapeutic agent delivery formulations

Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.

Modulation of HSP47 expression

Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.

Polyglutamate-amino acid conjugates and methods

Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.

Reduction of endotoxins from polyanionic polymer conjugates

Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-&#x3b3;-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.

Large scale process for preparing poly (glutamyl-glutamate) conjugates

This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.

Co-polymer conjugates

This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to polyglutamate amino acid conjugates that can include a linker to a compound that can include a drug, and their use for a variety of drug delivery applications, e.g., anticancer.

Polymer conjugates with a linker

Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications.

Biodegradable polyacetals for in vivo polynucleotide delivery

Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.

Compositions that include a hydrophobic compound and a polyamino acid conjugate

Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The transmembrane transporter compounds may include peptide nucleic acid monomer units.

Peptide nucleic  acid based guanidinium compounds

Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.

Biodegradable cationic polymers

Growing community of inventors

Carlsbad, CA, United States of America

Lei Yu