Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Lei Wu

Jingyi Wang

Lichun Wang

Hongmei Song

Qiang Tian

Jiaqiang Cai

Hong Zeng

Mingliang Zhao

Wei Zhong

Yongyong Wu

Donghai Su

Haitao Huang

Nan Yu

Hua Deng

Xin Zhou

Yuting Tan

Long Yang

The invention relates to a polyamide compound and a use thereof. Specifically, the invention relates to a type of polyamide compound (which preferably comprise one or more amide bonds formed by condensation of same or different L-amino acids or D-amino acids), or stereoisomers, crystalline polymorphs, solvates, metabolites, prodrugs or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with &#x3ba;-opioid receptor. The polyamide compound of the invention has excellent &#x3ba;-opioid receptor agonistic activity and hydrophilicity, thus having a lesser ability of penetrating the blood-brain barrier and a lower capacity for entering the brain. The compound of the invention has higher selectivity for a &#x3ba;-opioid receptor, lower addictiveness, improved pharmacokinetic properties, and improved safety (lower toxicity and/or fewer side effects), good patient compliance, and/or lesser propensity for developing tolerance, among other excellent medicinal properties.

Polyamide compound and use thereof

Growing community of inventors

Chengdu, China

Lei Wu