Ventana Medical Systems, Inc.

Aventis Pharmaceuticals Inc.

Lei Tang

Wenjun Zhang

Michael Patrick Farrell

Antony Hubbard

Brian Daniel Kelly

Donald D Johnson

Eric J May

Taylor J Shingler

Tsu-Shuen Tsao

Brian D Kelly

Craig P Smith

Sathapana Kongsamut

Donald Johnson

Lesli Baca Parkinson

Tobin Jones

Francis P Huger

Taylor Shingler

The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

Multiplexed immunohistochemistry using recombinant antibodies with epitope tags

Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.

Single-stranded oligonucleotide probes for chromosome or gene copy enumeration

Polymers and conjugates comprising polymers are disclosed herein. In some embodiments, the conjugates disclosed are suitable for use as detection probes in immunohistochemical assays, including multiplex immunohistochemical assays.

Polymers and conjugates comprising the same

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Oro Valley, AZ, United States of America

Lei Tang