Smith + Nephew

Amgen Inc.

Smith & Nephew Orthopaedics Ag

Dfb Technology, Ltd.

Abbvie Inc.

Encodia, Inc.

Abbvie Bahamas Limited

Lei Shi

Aleksa Jovanovic

Dennis A Carson

Eric Roche

Paul Renick

Duncan Aust

Michael R Schrimpf

William H Bunnelle

Tao Li

Catherine Van Der Kar

Chih-Hung Lee

Mark S Chee

Kevin L Gunderson

David Patrick Jones

Jianguo Ji

Rodger F Henry

Kevin B Sippy

Shuang Chen

Marc J Scanio

John M Beierle

Diana L Nersesian

Byeong Seon Chang

Michael Phillip Weiner

Ira M Herman

Bruce A Kerwin

Norihito Muranaka

Robert C James

Vitthal Kulkarni

Luca Monfregola

Promod Kumar

Vincent Ronfard

Byeong Chang

Marc Scanio

Geoff Gz Zhang

Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.

Dissolvable gel-forming film for delivery of active agents

Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.

Stable thermolysin hydrogel

Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising a synergistic combination of thermolysin and at least one aminoglycoside antibacterial agent.

Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces

Provided are methods for repairing a wound or inducing the proliferative phase of a wound comprising administering a composition comprising a protease mixture comprising collagenases and a neutral protease to the wound in an amount effective for repair of wound tissue or for inducing the proliferative phase in the wound.

Use ofprotease mixture in promoting wound healing

The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.

Synergistic antibacterial activity of medium polarity oils in combination with antibacterial agents on bacterial biofilms

Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising thermolysin.

Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces

Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising a synergistic combination of thermolysin and at least one aminoglycoside antibacterial agent.

A method of disrupting a bacterial biofilm present on a surface, comprising applying a composition that includes a semi-alkaline protease produced by the fermentation of the fungus(Seaprose) to the bacterial biofilm, wherein application of the composition to the bacterial biofilm disrupts the matrix of the bacterial biofilm.

Use of seaprose to remove bacterial biofilm

The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.

Enzymatic wound debriding compositions with enhanced enzymatic activity

Wound debridement compositions containing the proteolytic enzyme Seaprose and use of such compositions in wound treatment for the enzymatic debridement of wounds.

Wound debridement compositions containing seaprose and methods of wound treatment using same

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Mansfield, TX, United States of America

Lei Shi