Halozyme, Inc.

Unilever Plc

Lei Huang

H Michael Shepard

Ping Jiang

Xin Du

Gregory Ian Frost

Louis Howard Bookbinder

Ge Wei

Harold Michael Shepard

Daniel Edward Vaughn

Buxin Chen

Philip Lee Sheridan

Lalitha Kodandapani

Yubin Wang

Brian John Dobkowski

Marcina Siciliano

Zhichen Xu

Nimrod Hoofien

The present disclosure provides anti-amyloid β (Aβ) antibodies and antibody fragments that preferentially bind soluble amyloid Aβ protofibril/oligomer and trigger ADPC in microglial cells, anti-amyloid β (Aβ) antibodies and antibody fragments that reduce soluble amyloid Aβ protofibril/oligomer levels and insoluble amyloid Aβ plaque in brain tissue, and the use of anti-Aβ protofibril/oligomer antibodies and antibody fragments in therapy, prophylaxis, diagnosis, screening, and monitoring of conditions associated with Aβ protein aggregation, in particular Alzheimer's disease (AD).

Anti-amyloid beta protofibril/oligomer antibodies and uses thereof

Antibodies and antigen-binding fragments thereof that bind C1s and inhibit C1s activity and modulate the activity of at least one component in the classical pathway (CP) of complement activation, and methods for treating complement-mediated disorders using anti-C1s antibodies and fragments, are provided.

Anti-C1s antibodies and uses thereof

Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo environment compared to another in vivo environment. The methods include the steps of a) testing the activity of a protein under conditions in which normal or increased activity is desired; b) testing the activity of the protein under conditions in which reduced activity compared to normal is desired; and c) comparing the activity in a) with b) and selecting/identifying a protein that has greater activity in a) compared to b). The selected/identified protein is a conditionally active protein.

Methods for assessing and identifying or evolving conditionally active therapeutic proteins

Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the detection and quantification of hyaluronan in a biological sample and monitoring cancer treatment with an anti-hyaluronan agent, for example a hyaluronan-degrading enzyme, are provided. Combinations and kits for use in practicing the methods also are provided.

Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof

Growing community of inventors

San Diego, CA, United States of America

Lei Huang