Chongqing Upgra Biotechnology Co., Ltd.

Lei Huang

Huan Liu

Bin Wang

Qian Zhang

Dajun Li

Gaoquan Li

Jianhuan Li

Liangyan Peng

Tingting He

Yanyan Zhang

Yun Tang

Jvyuan Shui

Maofen Chen

Cuifang Zhang

Xiaodan Wu

Disclosed are an intermediate drug having synergistic anticancer activity and a polyethylene glycol-coupled synergistic anticancer drug, and a method preparing therefor and use thereof. The intermediate drug has the general structural formula of (I), and the polyethylene glycol-coupled synergistic anticancer drug has the general structural formula of (II). The drugs achieve the combined medication of various anticancer drugs and avoid the toxic reaction caused by the interaction among the drugs or by the pharmacokinetics of the drugs when taking various anticancer drugs, facilitate overcoming the multidrug resistance of cancers, have a synergistic effect, and can be used for preparing anticancer medicaments and for treating cancers.

Intermediate drug with synergistic anticancer activity and polyethylene glycol-coupled synergistic anticancer drug, and preparation method therefor and use thereof

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Chongqing, China

Lei Huang