Soochow University

Montage Technology (kunshan) Co., Ltd.

Suzhou Petmoda Technology Co., Ltd.

Yikang Biotech (suzhou) Co., Ltd.

Lei Chen

Tuo Shi

Meng Zhang

Li Chen

Zhixin Xia

Chao Wu

Jiachao Xu

Tao Fang

Sufang Gu

Wendie Wang

Songming He

Peizhe Li

Yujiao Song

Guangsha Zhang

Shibi Zhao

Yufei Gu

Jiadi Huang

Wenjuan Jiang

Jiaxin Lei

Xiaoya Ding

Mingze Shi

Yujuan Hua

Ruihong Jiang

Min Dai

Jianguo Yin

Tengsen Gao

Jiahao Xu

Eric Chen

Zongjie Hu

Xin Xie

Derong Wang

The present disclosure relates to the field of biomedicine, and in particular, to an improved mutant of a respiratory syncytial virus (RSV) fusion (F) protein and uses thereof. The mutant can form a trimeric structure without introducing a heterologous trimerization domain. Meanwhile, through mutation designs such as releasing internal electrostatic repulsion, deleting the furin cleavage site, truncating the C-terminal domain, and introducing interchain disulfide bonds, the protein is stabilized in the pre-fusion conformation and exhibits enhanced stability. The mutant in the present disclosure is highly immunogenic when used as a vaccine or a vaccine component and can induce the production of a high level of neutralizing antibodies in the immunized animal, which can be used in the preparation of a vaccine for the prevention or treatment of RSV infection, and can also be used as a reagent for the detection of RSV.

Mutants of respiratory syncytial virus fusion proteins

Cat litter box

A driving output circuit, a chip, and a driving output method are provided; the driving output circuit includes: a timer for outputting a timing signal; a bootstrap module for generating a first turn-on voltage based on an input signal; a charge pump for generating a second turn-on voltage based on the timing signal; a driving module including an upper driving MOSFET and a lower driving MOSFET connected to the upper driving MOSFET, and the upper driving MOSFET is connected to the lower driving MOSFET at a signal output; the first turn-on voltage and the second turn-on voltage are both used to turn on the upper driving MOSFET and/or the lower driving MOSFET to cause the signal output to output an output signal. The present disclosure provides a dynamic hybrid driving output circuit, which has improved gate oxide reliability and an enhanced anti-leakage function when not powered.

Driving output circuit, chip, and driving output method

Provided is a FeCrCuTiV high-entropy alloy powder for laser melting deposition manufacturing and a preparation method thereof, in percent by weight, the composition of the high-entropy alloy powder is: chromium 17-20%; copper 22-25%; titanium 16-19%; vanadium 17-20%; and ferrum 19-22%, wherein by utilizing the solid solution effect of alloying elements such as Ti, V and Cu of the high-entropy alloy, it can effectively alleviate the differences in thermal expansion coefficient, melting point, elastic modulus, etc. of the tungsten/steel or tungsten/copper heterogeneous interface, can reduce the residual stress level at the heterogeneous interface during the laser melting deposition manufacturing process and avoid the precipitation of Laves phase, and can meet the manufacturing requirements of tungsten/steel and tungsten/copper heterogeneous components for fusion reactors.

FeCrCuTiV high-entropy alloy powder for laser melting deposition manufacturing and preparation method thereof

Growing community of inventors

Suzhou, China

Lei Chen