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Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Nanjing Gear Pharma & Tech Co., Ltd.

Lei Chen

Xing Liu

Qing Dong

Piaoyang Sun

Jiong Lan

Hongjiang Xu

Ling Yang

Ye Edward Tian

Jian Zhou

Suixiong Cai

Xiaolong Wang

Lizhen Wu

Haijun Dong

Lijun Liu

Feng Yin

Wei Peng

Sheng Bi

Hongjian Jiang

Xiaolong Jiang

Anle Yang

Xiaohan Geng

Zenghui Yu

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a ROR&#x3b3; inhibitor, said compound has good ROR&#x3b3; inhibitory activity and is expected to be used for treating diseases mediated by a ROR&#x3b3; receptor in mammals. 

Sulfonyl substituted bicyclic compound which acts as ROR inhibitor

The present invention relates to a pyrrole sulfonamide derivative, a preparation method for the same, and medical applications thereof. Specifically, the present invention relates to a novel pyrrole sulfonamide derivative as represented by formula (I), a preparation method for the derivative, a pharmaceutical composition comprising the derivative, and uses of the same as therapeutic agents, and particularly as gastric acid secretion inhibitors and potassium-competitive acid blockers (P-CABs), wherein each substituent of formula (I) is as defined in the description. 

Pyrrole sulfonamide derivative, preparation method for same, and medical application thereof

Disclosed are 3-aryl-6-aryl-[1,2,4]triazolo[4,3-a]pyridines thereof, represented by the Formula (I) wherein Ar, Ar, R-Rare defined herein. Compounds having Formula (I) are inhibitors of cell proliferation. Therefore, compounds of the invention may be used to treat clinical conditions in which uncontrolled growth and spread of abnormal cells occurs. 

3-aryl-6-aryl-[1,2,4]triazolo[4,3-&#x3b1;]pyridines as inhibitors of cell proliferation and the use thereof

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Jiangsu, China

Lei Chen