Pacific Biosciences of California, Inc.

Leewin Chern

Satwik Kamtekar

Stephen T Yue

Erik Miller

Jeremiah Hanes

Lubomir Sebo

Ying Yang

Thomas Linsky

Keith P Bjornson

Steven Lin

Compositions comprising covalently modified and mutated biotin-binding proteins, particularly biotin-binding proteins having a negative charge at physiological pH, are provided. Methods of producing such proteins are also provided, as are methods of immobilizing, sequencing, and making nucleic acids employing such proteins.

Modified biotin-binding proteins for immobilization

The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites. In particular, the methods, compositions, and systems of the present invention result in an active loading of molecules and complexes into reaction sites with improved efficiency over loading by passive diffusion methods alone.

Methods and compositions for delivery of molecules and complexes to reaction sites

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Fremont, CA, United States of America

Leewin Chern