Serum Institute of India Private Limited

Leena Ravindra Yeolekar

Rajeev Mhalasakant Dhere

Rohit Bapurav Sonar

Milan Shomenath Ganguly

Umesh Gorakh Sagar

Cyrus Soli Poonawalla

Rajeev Mehla

Parikshit Dharampal Tyagi

Vinit Kumar

Shashikant Janardan Ghodekar

Yashodhan Dilip Anaspure

Sham Ramdas Tupe

Sandeep Dinkar Baraskar

Adar Cyrus Poonawalla

Swapnil Prabhakar Narale

The present disclosure provides compositions and methods for manufacturing and obtaining a live attenuated Influenza vaccine (LAIV) composition that can be delivered intranasally to provide protection against influenza virus infection. Said LAIV strains are based on cold adapted, temperature sensitive and attenuated phenotypes of master donor viruses (MDVs) containing the surface glycoprotein genes of the wild type pandemic or seasonal influenza strains. Also, said LAIV strains are further adapted to grow in MDCK cells (Madin Darby canine kidney cells). The use of eggs is avoided in large scale vaccine manufacturing. The purification process is devoid of chromatography steps. The said LAIV composition includes one or more live attenuated influenza vaccine virus and is devoid of polymers and surfactants.

Stabilized live attenuated influenza vaccine compositions

Stable lyophilized immunogenic compositions include inter alia live attenuated recombinant flaviviruses, more preferably live attenuated recombinant dengue viruses, at least one carbohydrate, at least one amino acid and is particularly amenable to rapid freeze-drying treatments wherein, the composition preserves desired characteristics of a virus, including virus viability, immunogenicity and stability. The immunogenic composition is devoid of preservatives, polymers and surfactants. The methods for manufacturing the stable lyophilized immunogenic compositions are also provided.

Stable vaccine compositions comprising inter alia live attenuated recombinant flavivirus and process for preparation thereof

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Pune Maharashtra, India

Leena Ravindra Yeolekar