Nabriva Therapeutics Ag

Nabriva Therapeutics Gmbh

Lee Spence

Werner Heilmayer

Rosemarie Riedl

Atchyuta Rama Chandra Murty Bulusu

Peter Hinsmann

The present invention relates to purification methods of pleuromutilin (I) by means of crystallisation and/or recrystallisation. The process according to the present invention is carried out in the presence of i-propylacetate. 

Purification of pleuromutilin

Process for the preparation of a compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a compound of formula IIa or in a mixture of a compound of formula IIa with a compound of formula IIb and isolating a compound of formula I from the reaction mixture; compounds and salts of compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a compound of formula I.

Process for the preparation of pleuromutilins

A compound of formula wherein PROT is an amine protecting group and PROT' is hydrogen; or PROT and PROT&#x2032; together with the nitrogen atom to which they are attached form a heterocyclic ring as an amine protecting group, and PROT&#x2033; is a thiol protecting group, processes for its production, intermediates in their production and production of intermediates in stereoisomerically pure form, and their use for the production of pharmaceutically active compounds.

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Vienna, Austria

Lee Spence