Pfizer Corporation

Pfizer Vaccines, Lcc

Other

Lee Richard Roberts

Nathan Anthony Logan Chubb

Lyn Howard Jones

Denis Billen

Kim Thomas Hall

Nigel Derek Arthur Walshe

Alan Daniel Brown

Brian Robert Champion

Robert L Dow

David W Piotrowski

Mark Edward Bunnage

David Morris Gethin

David Michael Wyatt

David Paul Gervais

Justin Stephen Bryans

Ariamala Gopalsamy

Bernard Joseph Banks

David Hepworth

Alan Stobie

David Cameron Pryde

Anne Maria Kristina Kjerrstrom

Agustin Casimiro-Garcia

Patrick Stephen Johnson

Ralph Pelton Robinson, Jr

Shawn Cabral

Mihir D Parikh

Graham Lunn

Michael Stephen Pacey

Mark A Haxell

Chulho Choi

Arjun Venkat Narayanan

Hatice Gizem Yayla

Jayasankar Jasti

Ming Zhu Chen

Olugbeminiyi Omezia Fadeyi

Clare Christy

Stephen Paul Gibson

Brian S Bronk

Thomas Ryckmans

Ivan Tommasini

Richard Edward Armer

Nathan Anthony Chubb

Kimberley Verrier

Toby James Underwood

Clare Lees

Nigel Derek Walshe

Helen Janet Mason

The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula (I) or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, Rand Rare as defined in the description. HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).

Chemical compounds

The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

IgE CH3 peptide vaccine

The present invention provides compounds of formula (I), or pharmaceutically acceptable derivatives thereof wherein the variables Z, Q, Ring A, V, X, Y and Y' are as defined herein, and pharmaceutical compositions comprising these compounds. The compounds of formula (I) and pharmaceutical compositions comprising them are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.

Compounds useful in therapy

This invention relates to a combination product comprising a compound of formula I wherein X, R, R, R, R, R, R, Rand Rare as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.

Substituted arylpyrazoles

This invention relates to a combination product comprising a range of 1-aryl-4 -cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents.

Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein:

Triazolyl piperidine arginine vasopressin receptor modulators

This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

The invention described herein relates to: the use of an effective inhibitor of a bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase in the manufacture of a composition for the treatment of acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase to a ruminant; a formulation suitable for the treatment of acidosis in an animal which comprises an effective inhibitor of a bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical/veterinary/farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase; a compound of the formula I: or veterinarily acceptable salt, solvate (including hydrate) or prodrug thereof; and processes to make an effective inhibitor of a bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase useful for the treatment of acidosis in a ruminant.

Treatment of rumen acidosis with &#x3b1;-amylase inhibitors

The invention described herein relates to: the use of an effective inhibitor of a bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase in the manufacture of a composition for the treatment of rumen acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase to a ruminant; a formulation suitable for the treatment of rumen acidosis in an animal which comprises an effective inhibitor of a bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical/veterinary/farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase; a compound of the formula I:or veterinarily acceptable salt, solvate (including hydrate) or prodrug thereof; and processes to make an effective inhibitor of a bacterial &#x3b1;-amylase and/or &#x3b1;-glucosidase useful for the treatment of acidosis in a ruminant.

Growing community of inventors

Sandwich, United Kingdom

Lee Richard Roberts