Nimura Genetic Solutions Co., Ltd.

Forest Research Institute Malaysia

Lee Li Tan

Shinichi Kondo

Seiji Shibahara

Hironobu Iinuma

Keiichi Numata

Siew Eim Khor

Yasuo Fukagawa

Kunimoto Hotta

Annie George

Satoshi Nimura

Szu Ting Ng

Noriyuki Okujo

Chin Jye Tan

Seven novel antibiotic substances can be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated assp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below:  These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in humans and animals.

Antibiotics, bispolides A1, A2, and A3 as well as bispolides B1, B2a, B2b and B3 and processes for producing said antibiotics

Growing community of inventors

Selangor, Malaysia

Lee Li Tan