Curis, Inc.

Harvard College

Children's Medical Center Corporation

Es Cell International Pte Ltd

Other

Nikon Corporation

The General Hospital Corporation

The Brigham and Women's Hospital, Inc.

Lee L Rubin

Oivin M Guicherit

Stephen Colin Price

Edward Andrew Boyd

Anthony David Baxter

Amy J Wagers

John Harry Alexander Stibbard

Lance Davidow

Feodor D Price

Amanda Gee

Maria Frank-Kamenetsky

Jeffrey A Porter

Jeffery Porter

Karen Kotkow

Stuart L Schreiber

Henryk T Dudek

Richard Theodore Lee

Douglas A Melton

Derrick J Rossi

Morag Helen Stewart

Shuibing C Chen

Kevin Pang

Kuanghui Lu

Wataru Ebina

Malgorzata Borowiak

Carmen Pepicelli

Lee F Peng

Irina Karavanov

Amanda K W Gee

Paula Gutierrez-Martinez

Kelvin Lam

Yasujiro Kiyota

Julia Lamenzo Fox

Chieko Nakada

Julia Lamenzo

Heidi C Horner

Theodore A Yednick

Seth Porter

Keiichi Niikura

Kathleen L Pfaff

Lida Katsimpardi

The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.

Small molecules for mouse satellite cell proliferation

The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGFβ signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.

Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance

Disclosed herein are methods for generating satellite cells and compositions including satellite cells.

Satellite cells and compositions and methods for producing the same

Methods of increasing satellite cell proliferation with vorinostat or bosutinib

Provided herein are methods for analysis of target cells on a population or individual basis, including before and after contact with a stimulus in order to determine the effect of such stimulus on the target cells. Also provided are devices for performing such methods. The analysis methods involve identifying and measuring or tracking morphological changes that occur in target cells over a period of time. Tracking is accomplished using imaging systems capable of imaging target cells individually over a period of time either continuously or at discrete intervals of time.

Methods and devices for live cell imaging analysis

The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF&#x3b2; signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.

Method of increasing satellite cell proliferation with an HDAC inhibitor

Methods of increasing satellite cell proliferation with kinase inhibitors

The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided is a method for repairing or regenerating a damaged muscle tissue of a subject.

Methods of increasing satellite cell proliferation

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting fromgain-of-function by contacting the cell with aantagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonizeactivity.

Mediators of hedgehog signaling pathways, compositions and uses related thereto

Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.

Compositions and methods for promoting the generation of PDX1+ pancreatic cells

The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS.and. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Small organic molecule regulators of cell proliferation

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Growing community of inventors

Wellesley, MA, United States of America

Lee L Rubin