Johnson Matthey Public Limited Company

Lee Jonathan Silverberg

Robert Hogan

Ronald Rossi

Ramesh M Shah

Michael Lawrence Casner

Theodore Maurice Resnick

A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically-acceptable solvent achieves room temperature stability for over 24 months. The acid improves the stability of the composition and the solvent enhances the solubility of the acid, thereby allowing the acid to have an improved stabilizing effect on the highly pure cannabinoid. Preferably, the solvent is an alcohol and, more preferably, the composition contains an oil. A method for making the composition includes combining the cannabinoid and the solvent and evaporating a portion of the solvent, along with adding an acid to the composition, before, during, or after the evaporating step. A method for making and storing the composition includes storing the composition in a manner adapted to maintain its stability. Pharmaceutical dosage forms include a formulated composition, such as having the oil. A method of treating a subject comprises administering to the subject the dosage form.

Method for making and storing stable cannabinoid compositions and method for treatment using such compositions

Stable cannabinoid compositions and methods for making and storing them

A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be &#x394;tetrahydrocannabinol, (&#x2212;)-&#x394;-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C-Calcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.

[object Object]

Composition comprising (&#x2212;)-&#x394;9-trans-tetrahydrocannabinol

The present invention relates to a process for the production of compound (A) comprising reacting compound (B) with compound (C). A further ring closure reaction may be necessary. The invention further relates to certain novel compounds of formula (B).

Synthesis of cannabinoids

The present invention relates to process wherein (+)-2-carene epoxide is coupled with a compound X&#x2014;Y that contains nucleophilic and electrophilic moieties, to produce a compound of formula (5). The reaction mixture consists essentially of a source of (+)-2-carene epoxide, compound X&#x2014;Y, optionally an inert solvent and optionally a pH buffer. No acid catalyst is used in the process.

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Cherry Hill, NJ, United States of America

Lee Jonathan Silverberg