Alfred E. Mann Foundation for Scientific Research

Second Sight Medical Products, Inc.

Pacesetter, Inc.

Ljm Associates, Inc.

Lee Jay Mandell

Joseph H Schulman

Robert Jay Greenberg

Richard P Williamson

Reza P Rassool

Abraham N Seidman

Ross Davis

Yitzhak Zilberman

Joan Golden Mandell

Gene A Bornzin

Anne Margaret Pianca

Euljoon Park

Joseph J Florio

Alan B Vogel

Junyu Mai

Richard J Nelson

Lung-Hsi Chu

Mark W Kroll

John Charles Gord

Charles L Byers

Carla M Mann

Gary D Schnittgrund

Martin J Vogel

Robert A Firth

Anthony D Falco

Richard David Mandell

Robert Dan Dell

David W Adinolfi

Brian J Lasater

Kate E Fey

Morten Hansen

Adam Vogel, Legal Representative

Gregoire Cosendai

Anne Marie Ripley

Christian Y Perron

Ytizhak Zilberman

Doug Kuschner

Ruth Turk

Jane Burridge

Scott V Notley

A method and apparatus for improving visual acuity when providing a visual image from a 'high' resolution input device to a 'low' resolution output device. The described invention is of particular use when the output device is an array of electrodes as part of a retinal prosthesis used to restore vision to a visually-impaired patient. In that various limitations may, within the foreseeable future, limit the density of such an electrode array (and thus the resolution of the output image), the present invention teaches techniques to assign processed pixel subsets of a higher resolution image to a single electrode. By varying the pixel subsets, e.g., by jittering, and/or altering the processing criteria, the perceived visual acuity may be further improved. Alternatively and additionally, such processing may be further extended to drive neighboring electrodes in combination to thus stimulate virtual electrode sites and thus further enhance visual acuity.

Video processing methods for improving visual acuity and/or perceived image resolution

A device configured for implantation beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle, stimulation and/or parameter monitoring and/or data communication. Devices in accordance with the invention are comprised of a sealed housing, typically having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm, containing a power source for powering electronic circuitry within. A placement structure is shown for facilitating placement of the implantable device proximate to neural/muscular tissue.

Structure for placement of an implantable device

A system and method that minimizes plaque accumulation on a stent and thereby restenosis that could require a subsequent invasive medical procedure following implantation of the stent in a patient. A plurality of electrically-powered, biocompatible devices, implantable via injection, are positioned within the patient proximate to the stent and under control of a externally-placed controller are commanded to emit ultrasonic waves corresponding to the mechanical resonance of the stent. By controlling the frequency and the relative phases of the ultrasonic waves, the accumulation of plaque on the stent can thus be minimized.

System of implantable ultrasonic emitters for preventing restenosis following a stent procedure

A method and apparatus for protecting an electronic implantable medical device prior to it being implanted in a patient's body. The apparatus affords protection against electronic component damage due to electrostatic discharge and/or physical damage due to improper handling. The apparatus is comprised of a circuit board having conductive surface means for receiving and releasably grasping the electrodes of the medical device to support the device's housing proximate to the surface of the circuit board. First and second conductive paths are formed on the circuit board extending between the first and second conductive surfaces for shunting electrostatic discharge currents to prevent such currents from passing through the device's electronic circuitry. The respective shunt paths include oppositely oriented diodes, preferably comprising diodes which emit light (i.e., LEDs) when current passes therethrough. Additionally, means are provided to enable functional testing of the medical device.

Protection apparatus for implantable medical device

A system and method that provide a prophylactic treatment to a person, e.g., a patient, to avoid the occurrence of pulmonary embolisms by the system providing neuromuscular stimulation to a person's lower extremities, e.g., the person's legs, when the system senses that a person has been immobile for an extended period of time. An implantable neuromuscular pacer, such as that described in U.S. Pat. Nos. 5,193,539; 5,193,540; 6,164,284; 6,185,452; 6,208,894; 6,315,721; 6,564,807; and their progeny, may be used to provide to selectively provide such stimulation. Preferably, such a device may be battery powered so that it can operate independent of an external apparatus. In particular, systems and devices of the present invention preferably additionally include an activity monitor, e.g., an accelerometer or the like, that disables or limits stimulation to pronged time periods in which there is limited activity.

Neuromuscular stimulation to avoid pulmonary embolisms

A system and method that facilitates stimulating neural pathways, e.g., muscles and/or associated nerves, of a patient's body for the purpose of therapeutic medical treatment by rehabilitating weakened muscles and using neuroplasticity to retrain sequential muscle movements and/or to provide the ability to directly deliver functional motor movements. Use of the present invention is of particular value for treating a patient following a stroke. More particularly, such systems are characterized by a plurality of discrete devices, preferably battery powered but may alternatively include RF-powered devices as well or in combination, configured for implanting within a patient's body via injection, each device being configured to affect a parameter, e.g., via nerve and/or muscle stimulation and/or to sense a body parameter, e.g., temperature, Ocontent, physical position, electrical potential, etc., that operate under control of a system controller that coordinates the sequential stimulation via wireless commands to the implanted devices.

System and method suitable for treatment of a patient with a neurological deficit by sequentially stimulating neural pathways using a system of discrete implantable medical devices

A method for facilitating placement of an implantable device configured for implantation beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle, stimulation and/or parameter monitoring and/or data communication. A placement structure is shown for facilitating placement of the implantable device proximate to neural/muscular tissue.

Method of placing an implantable device proximate to neural/muscular tissue

A method and apparatus for protecting an electronic implantable medical device prior to it being implanted in a patient's body. The apparatus affords protection against electronic component damage due to electrostatic discharge and/or physical damage due to improper handling. The apparatus is comprised of a circuit board having a conductive surface for receiving and releasably grasping the electrodes of the medical device to support the device's housing proximate to the surface of the circuit board. Two conductive paths are formed on the circuit board extending between two conductive surfaces for shunting electrostatic discharge currents to prevent such currents from passing through the device's electronic circuitry. The conductive paths include oppositely oriented diodes, preferably comprising diodes which emit light (i.e., LEDs) when current passes therethrough. Additionally, an external monitor/generator is provided to enable functional testing of the medical device.

A full-body charger for charging one or more battery-powered devices wherein such devices are configured for implanting beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle, stimulation and/or parameter monitoring and/or data communication. Devices in accordance with the invention include a support structure, typically chair-shaped or bed-shaped, capable of supporting a patient's body while providing a magnetic field to one or more of the implanted devices using one or more coils mounted within for providing power to the implanted devices. Consequently, in a preferred embodiment, a single, generally sequential, charging cycle can charge all of the implanted devices and thus minimize the charge time requirements for a patient and accordingly improve the patient's life style.

Full-body charger for battery-powered patient implantable device

An apparatus and packaging method for stacking a plurality of integrated circuit substrates, i.e., substrates having integrated circuits formed as integral portions of the substrates, which provides interconnection paths through the substrates to simplify electrical connections between the integrated circuits while facilitating minimization of the volume and customization of the three dimensional package size to conform to the available internal space within a housing, e.g., one used in an implantabie device where package volume is at a premium. Furthermore, an internal cavity can be created by the stacked formation that is suitable for mounting of a surface mount device, e.g., a crystal or the like.

Space-saving packaging of electronic circuits

A safety switch apparatus for disabling the operation of a hand-held appliance, e.g., a hair dryer, during periods of nonuse such as when the appliance is put down on a prescribed surface or placed in a non-functional position such as being held under a user's arm. In a first implementation, a sensor is coupled to control circuitry within the appliance to remove power from portions of the device, e.g., its motor and/or heater, when the appliance is proximate to an externally-provided magnetic field preferably provided from a magnetic element typically contained within a pad placeable on a work surface, within the work surface, or a wearable piece of clothing. In a second implementation, the converse occurs, i.e., a sensor is used to sense the presence of a user and to disable operation when the user is no longer present.

Proximity safety switch suitable for use in a hair dryer for disabling operation

A programmable signal analysis device for detecting and counting neurological and muscular events in living tissue that incorporates one or more signal threshold levels to identify an event, a counter to count events, and a timer to determine event frequency as events per unit time. The threshold levels and counter/timer operating modes/parameters are digitally programmable to identify and count events, i.e., electrical signals having defined parameters. Such a circuit is of particular use in a microstimulator/sensor which is capable of being injected into living tissue at the site of interest. The microstimulator/sensor is used to stimulate a neural pathway or muscle and/or to block a neural pathway to alleviate pain or block stimulation of a muscle.

Programmable signal analysis device for detecting neurological signals in an implantable device

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West Hills, CA, United States of America

Lee Jay Mandell