The United States of America, As Represented by the Secretary, Department of Health and Human Services

The United States of America As Represented by the Department of Health

Lee J Helman

Jay A Berzofsky

Leon T Van Den Broeke

Crystal L Mackall

Theresa J Goletz

Crystal MacKall

Disclosed are immunogenic peptides, related fusion proteins, nucleic acids encoding the peptides or fusion proteins, conjugates, expression vectors, host cells, and antibodies. Also, disclosed are pharmaceutical compositions, vaccines for use in the treatment or prevention of cancer, e.g., alveolar rhabodomyosarcoma, methods of stimulating a T cell to kill a tumor cell, methods of stimulating CD4and CD8T cells, and methods of treating or preventing cancer are further provided herein.

Immunogenic peptides and methods of use for treating and preventing cancer

A method of immunizing a mammal against a tumor cell by exposing splenic or peripheral blood mononuclear cells to a peptide that encompasses a fusion joint of a fusion protein encoded by DNA spanning a human chromosomal translocation associated with Ewing's sarcoma (t(11;22)(q24;q12)) or alveolar rhabdomyosarcoma (t(2:13)(q35;q14)) is provided.

Peptides containing a fusion joint of a chimeric protein encoded by DNA

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Bethesda, MD, United States of America

Lee J Helman