The University of Texas System

The Ohio State University

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Nanomedical Systems, Inc.

Lee Hudson

Randy Goodall

Mauro Ferrari

Alessandro Grattoni

Xuewu Liu

Ryan Medema

Sharath Hosali

Daniel Fine

Michael Crowley

Alessndro Grattoni

Xeuwu Liu

Devices and methods for administering a therapeutic agent, including an implantable delivery device. Exemplary embodiments include a reservoir in fluid communication with a channeled member, and a compound including the therapeutic agent and a solubilizer disposed within the reservoir.

Device and method for sustained release of low water solubility therapeutic agent in solubilizer

A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.

Nanochanneled device and related methods

A capsule configured for in vivo refilling of a therapeutic agent. In certain embodiments, the capsule may contain methotrexate.

A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate.

In an automatic weapon system such as the AR-15/M-16, the passage of propellant gas-carried heat, powder residues, and dirt to the bolt carrier and the upper receiver of the weapon is eliminated. The standard recoil spring housed in the buttstock of the weapon can be eliminated to produce a weapon with a folding stock or a machine pistol. Propelling gasses drive a piston which in turn drives a piston rod which is integrally coupled with the carrier key of the weapon. There is no relative movement between the rod and the carrier key. Therefore, no impact is delivered by the rod to the carrier. Longer carrier life is assured. The original recoil spring can be eliminated by a recoil spring on the piston rod. The ability to vary the volume of the gas chamber in which the piston is driven permits control of the firing rate of the weapon. A further enhancement permits the total blockage of propellant gasses from the gas cylinder so that the weapon may only be fired in a single action, single shot mode.

Recoil gas system for rifle

An improved muzzle brake having a generally upward opening void from which escaping gases create a downwardly directed reaction force and a sloping face on which the propelling gases collide and expand and deflect to either side and upward of the muzzle brake to defeat the natural tendency of the muzzle of a weapon to climb and drift. Below the generally upward opening void, within the floor of the bore of the muzzle is a venturi trough in which a lowered pressure region of propelling gases is created by the high speed passage of the propelling gases down to the bore of the muzzle brake. This lowered pressure region within the venturi trough is still in excess of the environmental pressure exterior of the muzzle brake so that gases within the venturi trough escape through channels directed downwardly and to the left and right of the projectile path. Gas escaping through these downward, left and right deflected channels is adjustable in flow so that any tendency of the weapon to drift left or right or to move downwardly may be compensated for. The muzzle brake has a structural shape which accommodates it to be fitted within a government issued flash hider. Once so housed within the flash hider, further modification is made to introduce retrojet gas escape channels through the walls of the flash hider into the bore through which the projectile and its propelling gases pass. Propelling gases escaping through these rearwardly directed retrojet channels offset the recoil of the weapon. By arraying these retrojet channels, a balanced set of reaction forces is derived which tends to offset transverse movement of the muzzle of the weapon.

Growing community of inventors

Elgin, TX, United States of America

Lee Hudson