Brightseed, Inc.

Sanford-Burnham Medical Research Institute

Sanford Burnham Prebys Medical Discovery Institute

Just, Inc.

Hampton Creek, Inc.

Lee Heil Chae

Chuan Wang

Meng Xu

Michael Brzustowicz

Fred Levine

Josh Stephen Tetrick

Matthew D Schultz

Nicolas Tilmans

James Flatt

Gabriel Navarro

Jessica Leigh Ochoa

Alexandra Marcela Herrmann

A method for modulating metabolism is provided which includes the step of providing a consumable composition including an extract containing a compound of Formula I to a subject in need thereof thereby modulating the subject's metabolism and addressing the underlying pathogenesis of metabolic disorders, such as nonalcoholic fatty liver disease, nonalcoholic steatohepatitis and type II diabetes mellitus.

Method for modulating metabolism

This disclosure relates to methods and compositions with enhanced levels of one or more tyramine containing hydroxycinnamic acid amides. Also disclosed herein are methods for producing a consumable product with enhanced levels of a tyramine containing hydroxycinnamic acid amide. Some embodiments relate to a composition enriched with a tyramine containing hydroxycinnamic acid.

Extract, consumable product and method for enriching bioactive metabolite in an extract

Systems and methods for assaying a test entity for a property, without measuring the property, are provided. Exemplary test entities include proteins, protein mixtures, and protein fragments. Measurements of first features in a respective subset of an N-dimensional space and of second features in a respective subset of an M-dimensional space, is obtained as training data for each reference in a plurality of reference entities. One or more of the second features is a metric for the target property. A subset of first features, or combinations thereof, is identified using feature selection. A model is trained on the subset of first features using the training data. Measurement values for the subset of first features for the test entity are applied to thereby obtaining a model value that is compared to model values obtained using measured values of the subset of first features from reference entities exhibiting the property.

Discovery systems for identifying entities that have a target property

Disclosed herein are methods for improving digestive health by providing a consumable composition. Some embodiments provided include, for example, administering a compound of Formula (I) or compound of Formula (II). Some embodiments provide the composition is formulated as a dietary supplement, food ingredient or additive, a medical food, nutraceutical or pharmaceutical composition.

Method for improving digestive health

Growing community of inventors

San Francisco, CA, United States of America

Lee Heil Chae