Vertex Pharmaceuticals, Inc.

Repare Therapeutics Inc.

Lee Fader

Tiansheng Wang

Francois Maltais

Brian Ledford

Jingrong Cao

Jon H Come

Claudio F Sturino

Suganthini S Nanthakumar

Warren A Dorsch

Elaine B Krueger

Timothy J Senter

Leslie A Dakin

Olivier Nicolas

Camil Sayegh

Janek Szychowski

Anne Fortier

Francois Denis

Martine Hamel

Stéphane Dorich

Vouy Linh Truong

Miguel St-Onge

Jean-François Truchon

Sheldon N Crane

Abbas Abdoli

Paul Jones

Audrey Picard

Stéphanie Lanoix

Cyrus M Lacbay

Cameron Black

Stephane Dorich

Stephanie Dorich

The disclosure provides at least one compound, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of formula (I), deuterated derivatives thereof, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of making and using the same, including use in treating APOL1 mediated kidney disease.

Inhibitors of APOL1 and methods of using same

Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as ATR kinase inhibitors

The disclosure provides at least one entity chosen from compounds of Formula (I)

Growing community of inventors

Hawkesbury, Canada

Lee Fader