Carnegie Mellon University

Allegheny-singer Research Institute

Other

Carmell Therapeutics Corporation

Westinghouse Electric Corporation

University of Pittsburgh

Carnell Therapeutics Corporation

Intermedics Inc.

Arco Medical Products Company

Setagon, Inc.

Lee E Weiss

Phil G Campbell

James E Burgess

Jason Smith

Fritz B Prinz

Michael L Reed

Prashant Nagesh Kumta

Takeo Kanade

Kenji Shimada

Gary Keith Fedder

Arthur C Sanderson

Norman Krause

Carmel Majidi

Christopher J Bettinger

Philip LeDuc

Jeffrey O Hollinger

Charles S Sfeir

Thomas A Mutschler

Shree K Nayar

Robert W Mendicino

E Levent Gursoz

Naser Naserifar

Jay Wynn Calvert

John Michael Stivoric

Kacey Gribbin Marra

Chris Dominick Kasabach

Daniel P Siewiorek

Friedrich B Prinz

Mark Zaremsky

Robert Merz

David A Simon

Fritz R Prinz

Daiwon Chol

Lawrence L Schultz

Daiwon Choi

Michael J Dalton

Gennady Yakovievitch Neplotnik

Scott J Cape

Clarence C Wu

Marc D Feldman

David M Sipe

Gregory W Fisher

Alan West

A flexible and stretchable integrated electronic device includes a substrate having a stiffness gradient, wherein a rigid electronic device is embedded within the substrate. The stiffness gradient within the substrate prevents delamination at the interface between the substrate and the embedded device. The stiffness gradient is accomplished by providing at least two distinct zones in the substrate with uniform stiffness, with each zone decreasing in stiffness as in a distance from the embedded device increases, or the gradient is accomplished by having a zone with a varying stiffness.

Integrated electronic device with flexible and stretchable substrate

A flexible and stretchable integrated electronic device comprising a substrate having a stiffness gradient, wherein a rigid electronic device is embedded within the substrate. The stiffness gradient within the substrate prevents delamination at the interface between the substrate and the embedded device. A method of fabricating an integrated electronic device having a stiffness gradient comprises applying a curing agent to an uncured polymer base material.

The disclosure describes a direct skeletal attachment (DSA) device including a micro-miniature chainmail skin-to-DSA interface. The interface comprises various porous architectures for skin ingrowth and integration as barriers against pathogens. Failure of skin-to-DSA interfaces can occur due to mismatches in mechanical compliance between pliable skin and more rigid DSA interfaces. To address this problem, in embodiments disclosed herein is an interface having a gradient in mechanical compliance or link mobility, ranging from fully flexible, to less compliant, to rigid where it attaches to the main DSA body.

Microminiature chainmail interface between skin and a transcutaneous prosthetic device and a method of manufacture

Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.

Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom

A method of making a bioplastic, and a bioplastic produced thereby, by using human plasma in which human plasma is clotted, either dried through its gel phase or dried and powdered, and processed into a bioplastic with the addition of at least one plasticizer followed by forming and heating to form a final bioplastic construct.

Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom

Systems and methods of generating updated surgical plans are described herein. In one embodiment, a method of generating an updated surgical plan can include generating a three dimensional (3D) model of a bone, generating a surgical plan based on the 3D model, in which the surgical plan can include: locations on the bone upon which to dispose a fixator and settings of struts of the fixator, disposing the fixator on the bone based on the surgical plan, and, based on data associated with the placement of the fixator disposed on the bone, generating an updated surgical plan including updated settings for the struts.

Computer-aided bone distraction

Provided is a method for production of nanocrystalline hydroxyapatite particles, and nanocrystalline hydroxyapatite particles produced according to the method. The nanocrystalline hydroxyapatite particles exhibit substantially superior cell transformation abilities as compared to known and commercially-available calcium phosphate kits. The nanocrystalline hydroxyapatite particles also find use in tissue engineering applications, for example bone and tooth engineering and repair applications.

Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids

Devices and methods for implementing computer-aided surgical procedures and more specifically devices and methods for implementing a computer-aided orthopedic surgery utilizing intra-operative feedback. A three-dimensional model of an area of a patient upon which a surgical procedure is to be performed is modeled using software techniques. The software model is used to generate a surgical plan, including placement of multifunctional markers, for performing the surgical procedure. After the markers are placed on the patient, an updated image of the patient is taken and used to calculate a final surgical plan for performing the remainder of the surgical procedure. The three-dimensional modeling, surgical planning, and surgery may all take place remote from each other. The various entities may communicate via an electronic communications network such as the Internet.

Computer-aided orthopedic surgery

Growing community of inventors

Pittsburgh, PA, United States of America

Lee E Weiss