Assembly Biosciences, Inc.

Indiana University

Lee Daniel Arnold

Hans Maag

William Wilson Turner, Jr

Leping Li

Mark G Bures

Simon Nicolas Haydar

Samson Francis

William W Turner

Adam Zlotnick

Lynne Bannen

Roopa Rai

Sreenivasa Reddy Mundla

William Turner

Mark Bures

Jr William W Turner

Simon Haydar

The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Hepatitis b core protein modulators

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.

Cyclic sulfamide compounds and methods of using same

The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp. 

Process for making Hepatitis B core protein modulators

The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound of formula: 

Hepatitis B core protein modulators

Hepatitis B core protein allosteric modulators

Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.

Hepatitis B viral assembly effectors

Growing community of inventors

Bloomington, IN, United States of America

Lee Daniel Arnold