Wyeth

Other

University of Arkansas

Lee Dalton Jennings

Geraldine Ruth McFarlane

Hassan Mahmoud Elokdah

Gregory Steven Basarab

Dennis R Rayner

David Zenan Li

David LeRoy Crandall

Scott Lee Kincaid

Derek Cecil Cole

Fuk-Wah Sum

Adam Matthew Gilbert

Ping Zhou

John W Ellingboe

Frank Eldridge Lovering

Lijing Chen

Eric Steven Manas

Joseph Raymond Stock

Koi Morris

William Jay Moore

Dennis William Powell

Yixian Zhang

Jeffrey Scott Condon

Matthew Gregory Bursavich

Hassan Mahmound Elokdah

Mohani Nirmala Sukhdeo

Junjun Wu

Yongbo Hu

The present invention relates to compounds of formula I: wherein R, R, R, R, R, and Rare defined herein.

Anilino-pyrimidine analogs

Compounds of formula I are provided: wherein: R1, R2, and R3, are as defined herein, as well as pharmaceutical composition and methods using the compounds as inhibitors of plasminogen activator inhibitor (PAI-1) and as therapeutic composition for treating conditions resulting from fibrinolytic disorders, such as deep vein thrombosis, coronary heart disease and pulmonary fibrosis.

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Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives of formula I are provided: 

The present invention provides an azolylacylquanidine compound of formula I  The present invention also provides methods for the use thereof to inhibit &#x3b2;-secretase (BACE) and treat &#x3b2;-amyloid deposits and neurofibrillary tangles.

Azolylacylguanidines as &#x3b2;-secretase inhibitors

This invention provides compounds of the formula: wherein: X is a chemical bond, &#x2014;CH&#x2014; or &#x2014;C(O)&#x2014;; Ris alkyl, cycloalkyl, &#x2014;CH-cycloalkyl, pyridinyl, &#x2014;CH-pyridinyl, phenyl or benzyl; Ris H, alkyl, cycloalkyl, &#x2014;CH-cycloalkyl, or perfluoroalkyl; Ris H, halo, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, &#x2014;CH-cycloalkyl, &#x2014;NH, or &#x2014;NO; Ris optionally substituted phenyl, benzyl, benzyloxy, pyridinyl, or &#x2014;CH-pyridinyl, or the salt or ester forms thereof, as well as methods for using the compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.

Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

The invention formula substituted 3-alkyl and 3-arylalkyl 1H indol-1yl acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor (PAI-1) useful for treating fibrinolytic disorders, the compounds having the structure wherein:

Compounds of Formula I are disclosed which are useful as fungicides wherein Also disclosed are compositions containing the compounds of Formula I and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula I.

Fungicidal amides

Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives of formula I are provided:  wherein: R, R, R, Rand Rare as defined herein which are useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) for treating conditions resulting from fibrinolytic disorders, such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.

Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

This invention provides compounds of the formula:wherein: X is a chemical bond, &#x2014;CH&#x2014; or &#x2014;C(O)&#x2014;; Ris alkyl, cycloalkyl, &#x2014;CH-cycloalkyl, pyridinyl, &#x2014;CH-pyridinyl, phenyl or benzyl; Ris H, alkyl, cycloalkyl, &#x2014;CH-cycloalkyl, or perfluoroalkyl; Ris H, halo, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, &#x2014;CH-cycloalkyl, &#x2014;NH, or &#x2014;NO; Ris optionally substituted phenyl, benzyl, benzyloxy, pyridinyl, or &#x2014;CH-pyridinyl, or the salt or ester forms thereof, as well as methods for using the compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.

Fungicidally active carboxylic acid amides

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Chestnut Ridge, NY, United States of America

Lee Dalton Jennings